Evidence map›Paper›PMID 9665979›Full record

ReviewClinical microbiology reviews1998

Dengue and dengue hemorrhagic fever.

D J Gubler

5 registry-linked trialsAbstract readReview
In one paragraph

Review in Clinical microbiology reviews, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 1,104 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,104citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00966628 phase3unknown statusnot on this mapstarted 2008, after this paper: background citation

The Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as a Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients

TypeinterventionalSponsorInnogene Kalbiotech Pte. LtdRan2008 to 2009Enrolled50ConditionsDengue Shock SyndromeArmsHypertonic sodium lactate, Ringer's lactate
NCT05452447 nacompletednot on this mapstarted 2023, after this paper: background citation

A Cluster Randomized, Placebo Control Trial to Evaluate the Efficacy of a Spatial Repellent (Mosquito ShieldTM) Against Aedes-borne Virus Infection Among Children ≥ 4-16 Years of Age in the Gampaha District, Sri Lanka

TypeinterventionalSponsorUniversity of Notre DameRan2023 to 2025Enrolled6,949ConditionsArbovirus InfectionsArmsTransfluthrin, Placebo
NCT05893134 completednot on this mapstarted 2023, after this paper: background citation

Identification of Risk Determinants of Dengue Transmission Through Landscape Analysis in the Neighborhood "El Vergel", Tapachula, Chiapas

TypeobservationalSponsorInstituto Mexicano del Seguro SocialRan2023 to 2024Enrolled196ConditionsDengueArmsRisk Assessment
NCT06891950 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

Phase 3B, Double-blind, Randomized Study to Evaluate the Safety and Non-inferiority of the Humoral Immune Response of the Butantan Dengue Vaccine in Participants Aged 60 to 79 Years Compared to Participants Aged 40 to 59 Years

TypeinterventionalSponsorButantan InstituteRan2026 to 2027Enrolled997ConditionsDengueArmsDengue 1,2,3,4 (attenuated) vaccine
NCT07409857 recruitingnot on this mapstarted 2025, after this paper: background citation

International Registry of Dengue Infection in Congenital Bleeding Disorders (DengueCBDR)

Typeobservational_patient_registrySponsorMahidol UniversityRan2025 to 2030Enrolled100ConditionsDengue Disease, Dengue Haemorrhagic Fever, Dengue Fever, Dengue Fever With Warning Signs
3 · Its place in the literature

Who cites it

1,104 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Dengue outbreaks in China during 2005-2023: a systematic analysis.Frontiers in cellular and infection microbiology · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. EliminatingInsects · 2026
    Article
  14. Article
  15. Dengue NS1 as a Driver of Immune-Mediated Pathogenesis.Tropical medicine and infectious disease · 2026
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

1,044 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

D J GublerDivision of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA. djg2@cdc.gov

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity (the cocirculation of multiple serotypes), and the emergence of dengue hemorrhagic fever in new geographic regions. In 1998 this mosquito-borne disease is the most important tropical infectious disease after malaria, with an estimated 100 million cases of dengue fever, 500,000 cases of dengue hemorrhagic fever, and 25,000 deaths annually. The reasons for this resurgence and emergence of dengue hemorrhagic fever in the waning years of the 20th century are complex and not fully understood, but demographic, societal, and public health infrastructure changes in the past 30 years have contributed greatly. This paper reviews the changing epidemiology of dengue and dengue hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both dengue fever and dengue hemorrhagic fever, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control. A major challenge for public health officials in all tropical areas of the world is to develop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.

Indexed as

DengueDengue VirusHumansIncidenceLatin AmericaSevere DengueTravelUnited StatesViral VaccinesViral Vaccines

Identifiers

PMID9665979
PMCPMC88892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.