ArticleClinical and diagnostic laboratory immunology1998
Lack of maternal antibodies to P serotypes may predispose neonates to infections with unusual rotavirus strains.
Article in Clinical and diagnostic laboratory immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings.Mucosal immunology · 2015Review
- Rotavirus genotype distribution during the pre-vaccine period in Bolivia: 2007-2008.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2013Article
- Factors that explain excretion of enteric pathogens by persons without diarrhea.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Article
- First detection of G12 rotaviruses in newborns with neonatal rotavirus infection at all India Institute of Medical Sciences, New Delhi, India.Journal of clinical microbiology · 2007Article
- Healthcare-associated infections in neonatal units: lessons from contrasting worlds.The Journal of hospital infection · 2007Review
- Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India.The Journal of infectious diseases · 2007Article
- Diagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen.Clinical and diagnostic laboratory immunology · 2004Article
- Hospital-acquired viral pathogens in the neonatal intensive care unit.Seminars in perinatology · 2002Review
- Detection and characterization of rotaviruses in hospitalized neonates in Blantyre, Malawi.Journal of clinical microbiology · 2002Article
- VP7 and VP4 genotyping of human group A rotavirus in Buenos Aires, Argentina.Journal of clinical microbiology · 2000Article
- Evidence of high-frequency genomic reassortment of group A rotavirus strains in Bangladesh: emergence of type G9 in 1995.Journal of clinical microbiology · 1999Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rotavirus (RV) strains infecting newborns often have unique neutralization antigens (P serotypes) on their outer capsids that are distinct from those found on RV strains that cause diarrhea in older children. We examined the hypothesis that unusual RV strains preferentially infect newborns because the newborns lack maternal neutralizing antibodies to these strains. To test this hypothesis, sera and saliva samples collected from neonates infected with 116E-like (P[11]G9) strains in the maternity ward of the All India Institute of Medical Sciences (AIIMS) hospital in New Delhi were tested for neutralizing antibodies against common RV strains and those infecting newborns and these titers were compared with those of newborns who did not become infected (controls). The infected neonates had significantly lower levels of cord blood neutralizing antibodies to 116E than the controls, suggesting that immunity to neonatal RV infection is acquired transplacentally through maternal antibodies. Further, this study confirmed the immunogenicity of the AIIMS neonatal strain 116E, a vaccine candidate, in its ability to evoke a potent RV-specific immunoglobulin A and neutralizing antibody response in serum and saliva among the infected babies. Our findings have important implications for the development of an effective RV vaccine. In India, where G9 strains are common in the community, the use of 116E as a vaccine, together with the rhesus tetravalent vaccine, may provide a broader protection against all the circulating RV serotypes, including serotype G9, which is not represented in the current rhesus RV tetravalent vaccine (G1-G4).
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