ArticleThe American journal of pathology1998
Loss of heterozygosity on chromosome 11p15 during histological progression in microdissected ductal carcinoma of the breast.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 27 citations in OpenAlex.
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- CD81 is a candidate tumor suppressor gene in human gastric cancer.Cellular oncology (Dordrecht, Netherlands) · 2013Article
- Expression of TIP30 tumor suppressor gene is down-regulated in human colorectal carcinoma.Digestive diseases and sciences · 2010Article
- Article
- The role of microsatellite instability at chromosome 11p15.5 in the progression of breast ductal carcinoma.Journal of Korean medical science · 2004Article
- Article
- Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression.Breast cancer research : BCR · 2001Article
- Loss of heterozygosity in fibrocystic change of the breast: genetic relationship between benign proliferative lesions and associated carcinomas.The American journal of pathology · 2000Article
- The long and short of chromosome 11 in breast cancer.The American journal of pathology · 1998Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Microdissection of histologically identifiable components from formalin-fixed, paraffin-embedded tissue sections allows molecular genetic analyses to be correlated directly with pathological findings. In this study, we have characterized loss of heterozygosity (LOH) at chromosome 11p15 at different stages of progression in microdissected tumor components from 115 ductal carcinomas of the breast. Microdissected foci of intraductal, infiltrating, and metastatic tumors were analyzed to determine the stage of progression at which LOH at 11p15 occurs. LOH was detected in 43 (37%) of 115 cases. Foci of intraductal carcinoma could be microdissected from 85 cases, of which 30 (35%) showed LOH at some stage of progression. LOH was detected in the intraductal component in 26 of these 30 cases. Interstitial deletions were characterized by using a panel of 10 highly polymorphic markers. The smallest region of overlap (SRO) for LOH at 11p15 was bounded by the markers D11S4046 and D11S1758. LOH at 11p15.5 showed no correlation with estrogen receptor status, the presence of positive lymph nodes, tumor size, histological grade, or long-term survival. We conclude that 11p15 LOH usually occurs early in breast cancer development but less frequently does not develop until the infiltrating or metastatic stages of tumor progression.
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