ArticleThe American journal of pathology1998
Characterization of keratinocyte growth factor and receptor expression in human pancreatic cancer.
Article in The American journal of pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 93 citations in OpenAlex.
- Plasma Levels of Keratinocyte Growth Factor Are Significantly Elevated for 5 Weeks After Minimally Invasive Colorectal Resection Which May Promote Cancer Recurrence and Metastasis.Frontiers in surgery · 2021Article
- Integrated Analysis of Structural Variation and RNA Expression of FGFR2 and Its Splicing Modulator ESRP1 Highlight theCancers · 2019Article
- Cultured Epidermal Melanocyte Transplantation in Vitiligo: A Review Article.Iranian journal of public health · 2019Review
- Emerging Roles of Fibroblast Growth Factor 10 in Cancer.Frontiers in genetics · 2018Article
- Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice.Acta histochemica et cytochemica · 2015Article
- Potential prognostic and diagnostic application of a novel monoclonal antibody against keratinocyte growth factor receptor.Molecular biotechnology · 2014Article
- Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases.Oncogene · 2014Article
- Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic cancer.Cancer science · 2014Article
- N-cadherin-mediated adhesion and signaling from development to disease: lessons from mice.Progress in molecular biology and translational science · 2013Review
- MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1.Carcinogenesis · 2012Article
- Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation.The American journal of pathology · 2012Article
- Keratinocyte growth factor induces matrix metalloproteinase-9 expression and correlates with venous invasion in pancreatic cancer.International journal of oncology · 2012Article
- Keratinocyte growth factor stimulates growth of MIA PaCa-2 cells through extracellular signal-regulated kinase phosphorylation.Oncology letters · 2012Article
- Analysis of pancreatic cancer microenvironment: role of macrophage infiltrates and growth factors expression.Journal of Cancer · 2012Article
- Fibroblast growth factor receptor 2: expression, roles, and potential as a novel molecular target for colorectal cancer.Pathology research international · 2012Article
- Monoclonal antibodies to fibroblast growth factor receptor 2 effectively inhibit growth of gastric tumor xenografts.Clinical cancer research : an official journal of the American Association for Cancer Research · 2010Article
- The role of fibroblast growth factors in tumor growth.Current cancer drug targets · 2009Review
- Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer.Human pathology · 2009Article
- Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.PloS one · 2009Article
- FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer.British journal of cancer · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Keratinocyte growth factor (KGF) is an angiogenic and mitogenic polypeptide that has been implicated in cancer growth and tissue development and repair. Its actions are dependent on its binding to a specific cell-surface KGF receptor (KGFR), which is encoded by the fibroblast growth factor (FGF) receptor type II (FGFR-2) gene. In the present study, we compared the immunohistochemical localization of KGF and KGFR/FGFR-2 in the normal and cancerous pancreas using specific antibodies that recognize KGF and KGFR/FGFR-2 and examined the expression of KGF, KGFR, and FGFR-2 in human pancreatic cancer by in situ hybridization with the corresponding riboprobes. In the normal pancreas, KGF immunoreactivity was present principally in the islet cells, whereas KGFR/FGFR-2 immunoreactivity was present both in the islet and ductal cells. In the pancreatic cancers, moderate KGF and moderate to strong KGFR/FGFR-2 immunoreactivity was present in many of the cancer cells. Furthermore, the ductal and acinar cells adjacent to the cancer cells exhibited moderate to strong KGF and KGFR/FGFR-2 immunoreactivity. By in situ hybridization, KGF, KGFR, and FGFR-2 were overexpressed and co-localized in the cancer cells within the pancreatic tumor mass but were even more abundant in the acinar and ductal cells adjacent to the cancer cells. These findings indicate that KGF, KGFR, and FGFR-2 are overexpressed in both the cancer cells and the adjacent pancreatic parenchyma and raise the possibility that KGF may act in an autocrine and paracrine manner to enhance pancreatic cancer cell growth in vivo.
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