ArticleIn vitro cellular & developmental biology. Animal1998
Macrophage cell lines derived from major histocompatibility complex II-negative mice.
Article in In vitro cellular & developmental biology. Animal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Phenotyping and susceptibility of established porcine cells lines to African Swine Fever Virus infection and viral production.Scientific reports · 2017Article
- Establishment and characterization of DB-1: a leptin receptor-deficient murine macrophage cell line.Cytotechnology · 2016Article
- Overexpression of IL-10 in C2D macrophages promotes a macrophage phenotypic switch in adipose tissue environments.PloS one · 2014Article
- Development and characterization of two porcine monocyte-derived macrophage cell lines.Results in immunology · 2013Article
- Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk.Nature immunology · 2011Article
- Evaluation of macrophage plasticity in brown and white adipose tissue.Cellular immunology · 2011Article
- Interactive changes between macrophages and adipocytes.Clinical and vaccine immunology : CVI · 2010Article
- Differentiation of C2D macrophage cells after adoptive transfer.Clinical and vaccine immunology : CVI · 2008Article
- Delayed clearance of Ehrlichia chaffeensis infection in CD4+ T-cell knockout mice.Infection and immunity · 2004Article
- Toll-like receptor 4-positive macrophages protect mice from Pasteurella pneumotropica-induced pneumonia.Infection and immunity · 2003Article
- Macrophage cell lines use CD81 in cell growth regulation.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two bone-marrow-derived macrophage cell lines, C2D and C2Dt, were isolated from major histocompatibility class II negative knock-out mice. The C2D cell line was stabilized by continuous culture in colony-stimulating factor-1 and the C2Dt cell line was transformed with SV40 virus large T antigen. These cells exhibited phenotypic properties of macrophages including morphology and expression of Mac 1 and Mac 2 cell surface molecules. These cells also had comparable growth to the bone-marrow-derived macrophage cell line B6MP102. These new cell lines were not spontaneously cytotoxic and were only capable of modest killing of F5b tumor cells when stimulated with LPS and interferon-gamma, but not when stimulated with LPS alone or with staphylococcal exotoxin. C2D and C2Dt cells phagocytosed labeled Staphylococcus aureus similarly to B6MP102 cells but less well than C2D peritoneal macrophages. These cell lines secreted interleukin-6, but not tumor necrosis factor or nitric oxide in response to LPS or staphlococcal enterotoxins A or B C2D(t) cells were tumorigenic in C2D and C57BL/6J mice but C2D cells were not. These data suggest that macrophage cell lines can be established from bone marrow cells of major histocompatibility complex II-negative mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.