ArticleThe Journal of physiology1998
Expression of functional GABAA receptors in cholecystokinin-secreting gut neuroendocrine murine STC-1 cells.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Prebiotic fructan chain length influences enteric microbiota-host GABAergic signaling and intestinal motility.The Journal of nutritional biochemistry · 2026Article
- Engaging Gut-to-Brain Signalling to Treat Alcohol Use Disorder.Addiction biology · 2026Article
- Nutrient Combinations Sensed by L-Cell Receptors Potentiate GLP-1 Secretion.International journal of molecular sciences · 2024Article
- Biliary Dyskinesia in Stiff Person Syndrome: An Association Between Reduced GABA Production and Gastroenteric Dysmotility.Journal of community hospital internal medicine perspectives · 2023Article
- Release of Cholecystokinin from Rat Intestinal Mucosal Cells and the Enteroendocrine Cell Line STC-1 in Response to Maleic and Succinic Acid, Fermentation Products of Alcoholic Beverages.International journal of molecular sciences · 2020Article
- Role of the brain-gut axis in gastrointestinal cancer.World journal of clinical cases · 2019Review
- Molecular Characterization of GABA-A Receptor Subunit Diversity within Major Peripheral Organs and Their Plasticity in Response to Early Life Psychosocial Stress.Frontiers in molecular neuroscience · 2018Article
- Stimulation of incretin secreting cells.Therapeutic advances in endocrinology and metabolism · 2016Review
- Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop.Oncotarget · 2016Article
- GABAAα1 and GABAAρ1 subunits are expressed in cultured human RPE cells and GABAA receptor agents modify the intracellular calcium concentration.Molecular vision · 2015Article
- Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Identification of GABA receptors in chick cornea.Molecular vision · 2012Article
- GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches.Physiology (Bethesda, Md.) · 2009Review
- An enteroendocrine cell-based model for a quiescent intestinal stem cell niche.Cell proliferation · 2006Article
- The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line.The Journal of physiology · 2005Article
- Article
- A novel approach in the treatment of neuroendocrine gastrointestinal tumours. Targeting the epidermal growth factor receptor by gefitinib (ZD1839).British journal of cancer · 2003Article
- Subunit composition and function of GABAA receptors of rat spermatozoa.Neurochemical research · 2002Article
- Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y(2)-receptors.British journal of cancer · 2002Article
- Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells.British journal of cancer · 2001Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Gastrointestinal neuroendocrine (NE) cells synthesize, store and secrete gamma-aminobutyric acid (GABA). Recently, an autocrine-paracrine function of GABA has been proposed for secretion from NE cells. 2. To search for functional GABAA receptors in NE gut cells, we performed whole-cell and perforated-patch-clamp studies in the intestinal cholecystokinin (CCK)-secreting NE cell line STC-1. 3. Application of GABA evoked currents in STC-1 cells. These effects were mimicked by muscimol, an agonist of GABAA receptors, and blocked by picrotoxin or bicuculline, antagonists of GABAA receptors. The GABA- or muscimol-activated currents reversed near 0 mV, which under the recording conditions used was consistent with the activation of the GABAA receptor-Cl- channel complex. 4. In contrast to the effect on most neurons, GABA as well as muscimol led to a (reversible) depolarization of the membrane potential of STC-1 cells. Membrane depolarization in turn activated voltage-gated Ca2+ channels and increased intracellular Ca2+ concentrations in STC-1 cells. 5. In accordance with the observed membrane depolarization and activation of voltage-gated Ca2+ channels, both GABA and muscimol stimulated Ca2+-dependent CCK release. In contrast, bicuculline inhibited the GABA-induced secretion of CCK. 6. Using the reverse transcription-polymerase chain reaction (RT-PCR), mRNA of the GABAA receptor subunits alpha2, alpha3, alpha5, beta1, beta3 and delta could be detected in STC-1 cells. 7. In summary, we have shown that the CCK-secreting gut NE cell line STC-1 expresses functional GABAA receptors and that GABA stimulates CCK release. Thus, GABA is involved in the fine tuning of CCK secretion from the gut NE cell line STC-1.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.