ArticleThe Journal of cell biology1998
Structural requirements for outside-in and inside-out signaling by Drosophila neuroglian, a member of the L1 family of cell adhesion molecules.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- L1 coupling to ankyrin and the spectrin-actin cytoskeleton modulates ethanol inhibition of L1 adhesion and ethanol teratogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons.Frontiers in cell and developmental biology · 2016Review
- L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture.The Journal of cell biology · 2015Article
- Mitogen-activated protein kinase modulates ethanol inhibition of cell adhesion mediated by the L1 neural cell adhesion molecule.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Transsynaptic coordination of synaptic growth, function, and stability by the L1-type CAM Neuroglian.PLoS biology · 2013Article
- The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development.Development (Cambridge, England) · 2011Article
- Perisomatic GABAergic innervation in prefrontal cortex is regulated by ankyrin interaction with the L1 cell adhesion molecule.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
- Polarized targeting of L1-CAM regulates axonal and dendritic bundling in vitro.The European journal of neuroscience · 2010Article
- Inside-out regulation of L1 conformation, integrin binding, proteolysis, and concomitant cell migration.Molecular biology of the cell · 2010Article
- Article
- Cryo-electron tomography of homophilic adhesion mediated by the neural cell adhesion molecule L1.Structure (London, England : 1993) · 2009Article
- The interaction between L1-type proteins and ankyrins--a master switch for L1-type CAM function.Cellular & molecular biology letters · 2009Review
- Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation.Journal of neuroscience research · 2008Article
- The lateral mobility of cell adhesion molecules is highly restricted at septate junctions in Drosophila.BMC cell biology · 2008Article
- The L1-type cell adhesion molecule Neuroglian is necessary for maintenance of sensory axon advance in the Drosophila embryo.Neural development · 2008Article
- L1 interaction with ankyrin regulates mediolateral topography in the retinocollicular projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila.Genetics · 2006Article
- MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth.Molecular biology of the cell · 2006Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of the Drosophila cell adhesion molecule neuroglian in S2 cells leads to cell aggregation and the intracellular recruitment of ankyrin to cell contact sites. We localized the region of neuroglian that interacts with ankyrin and investigated the mechanism that limits this interaction to cell contact sites. Yeast two-hybrid analysis and expression of neuroglian deletion constructs in S2 cells identified a conserved 36-amino acid sequence that is required for ankyrin binding. Mutation of a conserved tyrosine residue within this region reduced ankyrin binding and extracellular adhesion. However, residual recruitment of ankyrin by this mutant neuroglian molecule was still limited to cell contacts, indicating that the lack of ankyrin binding at noncontact sites is not caused by tyrosine phosphorylation. A chimeric molecule, in which the extracellular domain of neuroglian was replaced with the corresponding domain from the adhesion molecule fasciclin II, also selectively recruited ankyrin to cell contacts. Thus, outside-in signaling by neuroglian in S2 cells depends on extracellular adhesion, but does not depend on any unique property of its extracellular domain. We propose that the recruitment of ankyrin to cell contact sites depends on a physical rearrangement of neuroglian in response to cell adhesion, and that ankyrin binding plays a reciprocal role in stabilizing the adhesive interaction.
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