ArticleThe Journal of cell biology1998
Stabilization and localization of Xist RNA are controlled by separate mechanisms and are not sufficient for X inactivation.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 96 citations in OpenAlex.
- Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids.Genome research · 2022Article
- Review
- Probing the function of long noncoding RNAs in the nucleus.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Review
- Escape From X-Chromosome Inactivation: An Evolutionary Perspective.Frontiers in cell and developmental biology · 2019Review
- CRISPR/Cas9-mediated modulation of splicing efficiency reveals short splicing isoform of Xist RNA is sufficient to induce X-chromosome inactivation.Nucleic acids research · 2018Article
- Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming.Nature communications · 2016Article
- Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos.Cell · 2016Article
- From discovery to function: the expanding roles of long noncoding RNAs in physiology and disease.Endocrine reviews · 2015Review
- Derivation of consensus inactivation status for X-linked genes from genome-wide studies.Biology of sex differences · 2015Article
- Differentially methylated CpG island within human XIST mediates alternative P2 transcription and YY1 binding.BMC genetics · 2014Article
- Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci.Epigenetics & chromatin · 2014Article
- Minireview: Long noncoding RNAs: new "links" between gene expression and cellular outcomes in endocrinology.Molecular endocrinology (Baltimore, Md.) · 2013Review
- Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2011Review
- A scaffold for X chromosome inactivation.Human genetics · 2011Review
- Article
- Molecular and DNA methylation analysis of Peg10 and Xist gene in sheep.Molecular biology reports · 2011Article
- Article
- XIST RNA and architecture of the inactive X chromosome: implications for the repeat genome.Cold Spring Harbor symposia on quantitative biology · 2010Review
- Lessons from comparative analysis of X-chromosome inactivation in mammals.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Review
- X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected.Journal of cellular physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
These studies address whether XIST RNA is properly localized to the X chromosome in somatic cells where human XIST expression is reactivated, but fails to result in X inactivation (Tinker, A.V., and C.J. Brown. 1998. Nucl. Acids Res. 26:2935-2940). Despite a nuclear RNA accumulation of normal abundance and stability, XIST RNA does not localize in reactivants or in naturally inactive human X chromosomes in mouse/ human hybrid cells. The XIST transcripts are fully stabilized despite their inability to localize, and hence XIST RNA localization can be uncoupled from stabilization, indicating that these are separate steps controlled by distinct mechanisms. Mouse Xist RNA tightly localized to an active X chromosome, demonstrating for the first time that the active X chromosome in somatic cells is competent to associate with Xist RNA. These results imply that species-specific factors, present even in mature, somatic cells that do not normally express Xist, are necessary for localization. When Xist RNA is properly localized to an active mouse X chromosome, X inactivation does not result. Therefore, there is not a strict correlation between Xist localization and chromatin inactivation. Moreover, expression, stabilization, and localization of Xist RNA are not sufficient for X inactivation. We hypothesize that chromosomal association of XIST RNA may initiate subsequent developmental events required to enact transcriptional silencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.