ArticleThe American journal of tropical medicine and hygiene1998
A target for intervention in Plasmodium falciparum infections.
Article in The American journal of tropical medicine and hygiene, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- Gametocytemia in Plasmodium vivax and Plasmodium falciparum infections.The Journal of parasitology · 2006Article
- Competition for red blood cells can enhance Plasmodium vivax parasitemia in mixed-species malaria infections.The American journal of tropical medicine and hygiene · 2006Article
- Age-structured red blood cell susceptibility and the dynamics of malaria infections.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Top-down or bottom-up regulation of intra-host blood-stage malaria: do malaria parasites most resemble the dynamics of prey or predator?Proceedings. Biological sciences · 2003Article
- Plasmodium malariae infection boosts Plasmodium falciparum gametocyte production.The American journal of tropical medicine and hygiene · 2002Article
- Plasmodium vivax blood-stage dynamics.The Journal of parasitology · 2002Article
- Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections.The American journal of tropical medicine and hygiene · 1999Article
- Multispecies Plasmodium infections of humans.The Journal of parasitology · 1999Review
- Discrete-Event Simulation Models of Plasmodium falciparum Malaria.Simulation · 1998Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
We present a set of simple mathematical models to investigate interactions between malaria parasites and the human immune system and the differentiation of parasites from asexual, pathogenic into sexual, transmissible blood stages. Each model represents a different combination of empirically based hypotheses, and salient behaviors of each fit criteria developed from clinical data. In all models, however, higher gametocyte conversion rates result in lower peak asexual-form densities. Therefore, to the extent that asexual-form densities are associated with disease symptoms, interventions that stimulate gametocytogenesis should produce unexpected clinical benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.