ArticleJournal of clinical pathology1998
Fine needle aspiration cytology diagnosis of malignant lymphoma and reactive lymphoid hyperplasia.
Article in Journal of clinical pathology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- From Granulomas to Malignancy: Validating the Sydney System in a Tuberculosis-Endemic Landscape.Cureus · 2026Article
- Role of immunohistochemistry in differentiating between reactive and malignant lymphoid hyperplasia - A cross-sectional study.Bioinformation · 2025Article
- Corneoconjunctival manifestations of lymphoma in three dogs.Journal of veterinary science · 2019Article
- Histological Surprises in Benign Cytologies after Lymph Node Biopsy-Surgeon's Knife Improving Patient Care.Indian journal of surgical oncology · 2017Article
- Eosinophilia and multiple lymphadenopathy: Kimura disease, a rare, but benign condition.BMJ case reports · 2016Article
- Clonality and phenotyping of canine lymphomas before chemotherapy and during remission using polymerase chain reaction (PCR) on lymph node cytologic smears and peripheral blood.The Canadian veterinary journal = La revue veterinaire canadienne · 2010Article
- Role of polymerase chain reaction and immunocytochemistry in the cytological assessment of lymphoid proliferations.Journal of clinical pathology · 2006Article
- Fine needle aspiration cytology in the diagnosis of uncommon types of lymphoma.Journal of clinical pathology · 2003Article
- Fine needle aspiration of lymph nodes.Journal of clinical pathology · 1998Review
- Fine-Needle Aspiration Diagnosis of Lymphoma Based on Cytomorphology Alone: How Accurate is it? - A Cyto-Histopathology Correlative Study.Journal of cytologyArticle
- Comparison of liquid-based preparation and conventional smear of fine-needle aspiration cytology of lymph node.Journal of cytologyArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess the diagnostic accuracy of lymph node fine needle aspiration (FNA) cytology to distinguish reactive lymphoid hyperplasia from malignant lymphoma, and to evaluate the contribution of ancillary techniques applied to cytological material.
methodsTwo hundred and seventy seven consecutive lymph node FNA specimens reported to be consistent with reactive lymphoid hyperplasia (n = 213) or suggestive/diagnostic of malignant lymphoma (n = 64) were reviewed. Follow up data were obtained by case record review or by histological correlation. The value of immunocytochemistry, in situ hybridisation for immunoglobulin light chain mRNA, and polymerase chain reaction (PCR) towards the final clinicopathological diagnosis was assessed in 92, 61, and 45 cases, respectively.
resultsSixty one of 67 lymphomas and 207 of 209 reactive lymph nodes were accurately diagnosed by FNA cytology. There were six false negative aspirates including three cases of follicular lymphoma, two cases of Hodgkin's disease, and one chronic lymphocytic leukaemia. Two FNA specimens considered suspicious of lymphoma proved reactive on histology or clinical follow up. One metastatic small cell carcinoma was wrongly diagnosed as lymphoma. Ancillary studies contributed to the correct diagnosis in most cases although occasional misleading results were obtained, particularly with PCR.
conclusionsFNA cytology accurately distinguished reactive lymphoid hyperplasia from malignant lymphoma in 97% of cases. However, occasional wrong diagnoses occurred owing to sampling error or misinterpretation. Ancillary studies can be applied to cytological samples and contribute to the diagnosis in most cases.
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