ArticleGut1998
Tumour necrosis factor-alpha enhances intraepithelial lymphocyte proliferation and migration.
Article in Gut, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 37 citations in OpenAlex.
- CXCL9 and IL-18: potential biomarkers for efficacy evaluation in refractory hemophagocytic lymphohistiocytosis treated with RED (ruxolitinib, emapalumab and dexamethasone).Annals of hematology · 2025Article
- Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.Nature communications · 2019Article
- [Clinical significance of serum calcium and albumin in patients with secondary hemophagocytic lymphohistiocytosis].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- Boron Induces Lymphocyte Proliferation and Modulates the Priming Effects of Lipopolysaccharide on Macrophages.PloS one · 2016Article
- Article
- Expansion and activation kinetics of immune cells during early phase of GVHD in mouse model based on chemotherapy conditioning.Clinical & developmental immunology · 2010Article
- Small bowel review: normal physiology part 2.Digestive diseases and sciences · 2001Review
- Lamina propria lymphocytes produce interferon-gamma and develop suppressor activity in response to lactoglobulin.Digestive diseases and sciences · 2001Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundTumour necrosis factor alpha (TNF-alpha) is a proinflammatory cytokine found in abundance in diseased intestine.
aimsThe T cell production of TNF-alpha and the impact of this cytokine on intestinal T cell proliferation, migration, and cytotoxicity were studied.
methodsIntestinal lymphocytes from normal jejunum were used. TNF-alpha production in culture supernates was measured by enzyme linked immunosorbent assay (ELISA). Lymphocyte proliferation was measured using 3H thymidine uptake; migration, using transwell chambers; and cytotoxicity of HT-29 colon cancer cells, using the chromium-51 release assay.
resultsTNF-alpha was produced mainly by the CD8+ T cells in the intraepithelial lymphocytes (IEL) and the CD4+ T cells in the lamina propria lymphocytes in response to CD2 stimulation: 478 (94) and 782 (136) pg/ml, respectively. TNF-alpha (1 ng/ml or greater) augmented proliferation of IEL in response to interleukin 2 (IL-2), IL-7, or antibody to CD3 due to increased activation that did not involve IL-2 production or receptor generation. Conversely, antibody to TNF-alpha reduced IEL proliferation in response to IL-2 or IL-7. TNF-alpha also induced calcium mobilisation and chemokinesis (by 2.8 (0.5) fold over spontaneous migration). TNF-alpha had no effect on lymphokine activated killer cell activity.
conclusionsTNF-alpha increases the proliferation and migration of IEL, which may expand their number in the epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.