ArticleMolecular biology of the cell1998
Multiple functions for actin during filamentous growth of Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring roles for essential proteins in yeast filamentous growth identifies the WASP homolog Las17 as a regulator of the Cdc42-dependent fMAPK pathway.bioRxiv : the preprint server for biology · 2026Article
- Spatial structure of yeast biofilms and the role of cell adhesion across different media.Biofilm · 2025Article
- Saccharomyces cerevisiae does not undergo a quorum sensing-dependent switch of budding pattern.Scientific reports · 2022Article
- Actin Cytoskeleton Regulation by the Yeast NADPH Oxidase Yno1p Impacts Processes Controlled by MAPK Pathways.Antioxidants (Basel, Switzerland) · 2021Article
- Filamentation Involves Two Overlapping, but Distinct, Programs of Filamentation in the Pathogenic FungusG3 (Bethesda, Md.) · 2017Article
- Role of phosphatidylinositol phosphate signaling in the regulation of the filamentous-growth mitogen-activated protein kinase pathway.Eukaryotic cell · 2015Article
- Article
- Ras GTPase-activating protein regulation of actin cytoskeleton and hyphal polarity in Aspergillus nidulans.Eukaryotic cell · 2008Article
- Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growth.Eukaryotic cell · 2005Article
- Identification of growth phenotype-related genes in Aspergillus oryzae by heterologous macroarray and suppression subtractive hybridization.Molecular genetics and genomics : MGG · 2005Article
- Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth.Molecular biology of the cell · 2004Article
- Guanyl nucleotide exchange factor Sql2 and Ras2 regulate filamentous growth in Ustilago maydis.Eukaryotic cell · 2003Article
- Myosin I is required for hypha formation in Candida albicans.Eukaryotic cell · 2002Article
- Enhanced cell polarity in mutants of the budding yeast cyclin-dependent kinase Cdc28p.Molecular biology of the cell · 2001Article
- Candida albicans INT1-induced filamentation in Saccharomyces cerevisiae depends on Sla2p.Molecular and cellular biology · 2001Article
- Different domains of the essential GTPase Cdc42p required for growth and development of Saccharomyces cerevisiae.Molecular and cellular biology · 2001Article
- Structure-function relationships in yeast tubulins.Molecular biology of the cell · 2000Article
- The secretory pathway mediates localization of the cell polarity regulator Aip3p/Bud6p.Molecular biology of the cell · 2000Article
- Regulation of G2/M progression by the STE mitogen-activated protein kinase pathway in budding yeast filamentous growth.Molecular biology of the cell · 1999Article
- Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.Microbiology and molecular biology reviews : MMBR · 1999Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Saccharomyces cerevisiae is dimorphic and switches from a yeast form to a pseudohyphal (PH) form when starved for nitrogen. PH cells are elongated, bud in a unipolar manner, and invade the agar substrate. We assessed the requirements for actin in mediating the dramatic morphogenetic events that accompany the transition to PH growth. Twelve "alanine scan" alleles of the single yeast actin gene (ACT1) were tested for effects on filamentation, unipolar budding, agar invasion, and cell elongation. Some act1 mutations affect all phenotypes, whereas others affect only one or two aspects of PH growth. Tests of intragenic complementation among specific act1 mutations support the phenotypic evidence for multiple actin functions in filamentous growth. We present evidence that interaction between actin and the actin-binding protein fimbrin is important for PH growth and suggest that association of different actin-binding proteins with actin mediates the multiple functions of actin in filamentous growth. Furthermore, characterization of cytoskeletal structure in wild type and act1/act1 mutants indicates that PH cell morphogenesis requires the maintenance of a highly polarized actin cytoskeleton. Collectively, this work demonstrates that actin plays a central role in fungal dimorphism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.