ArticleMolecular biology of the cell1998
Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development.
Article in Molecular biology of the cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- The Biological Significance of Trogocytosis.Results and problems in cell differentiation · 2024Article
- The Membrane-Bound Notch Regulator Mnr Supports Notch Cleavage and Signaling Activity inBiomolecules · 2021Article
- An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning.BMC systems biology · 2019Article
- Kinase programs spatiotemporally regulate gap junction assembly and disassembly: Effects on wound repair.Seminars in cell & developmental biology · 2016Review
- Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.Pharmacology & therapeutics · 2015Review
- Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition.Journal of cell science · 2013Article
- Drosophila mauve mutants reveal a role of LYST homologs late in the maturation of phagosomes and autophagosomes.Traffic (Copenhagen, Denmark) · 2012Article
- Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling.Molecular and cellular biology · 2012Article
- dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions.The Journal of cell biology · 2012Article
- No evidence for a functional role of bi-directional Notch signaling during angiogenesis.PloS one · 2012Article
- The role of Adams in Notch signaling.Advances in experimental medicine and biology · 2012Review
- Notch signalling in solid tumours: a little bit of everything but not all the time.Nature reviews. Cancer · 2011Review
- The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors.Acta histochemica · 2011Review
- Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking.Development (Cambridge, England) · 2010Article
- Endocytosis and intracellular trafficking of Notch and its ligands.Current topics in developmental biology · 2010Review
- Canonical and non-canonical Notch ligands.Current topics in developmental biology · 2010Review
- Drosophila Sec16 mediates the biogenesis of tER sites upstream of Sar1 through an arginine-rich motif.Molecular biology of the cell · 2008Article
- The many facets of Notch ligands.Oncogene · 2008Review
- DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur.The Journal of cell biology · 2007Article
- The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling.Molecular biology of the cell · 2007Article
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Authors and funding
3 authors.
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Abstract
Delta functions as a cell nonautonomous membrane-bound ligand that binds to Notch, a cell-autonomous receptor, during cell fate specification. Interaction between Delta and Notch leads to signal transduction and elicitation of cellular responses. During our investigations to further understand the biochemical mechanism by which Delta signaling is regulated, we have identified four Delta isoforms in Drosophila embryonic and larval extracts. We have demonstrated that at least one of the smaller isoforms, Delta S, results from proteolysis. Using antibodies to the Delta extracellular and intracellular domains in colocalization experiments, we have found that at least three Delta isoforms exist in vivo, providing the first evidence that multiple forms of Delta exist during development. Finally, we demonstrate that Delta is a transmembrane ligand that can be taken up by Notch-expressing Drosophila cultured cells. Cell culture experiments imply that full-length Delta is taken up by Notch-expressing cells. We present evidence that suggests this uptake occurs by a nonphagocytic mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.