ArticleJournal of virology1998
Maintenance of an intact human immunodeficiency virus type 1 vpr gene following mother-to-infant transmission.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- HIV-1 Vpr induces ciTRAN to prevent transcriptional repression of the provirus.Science advances · 2023Article
- Illuminating the Role of Vpr in HIV Infection of Myeloid Cells.Frontiers in immunology · 2019Review
- The HIV-1 Vpr Protein: A Multifaceted Target for Therapeutic Intervention.International journal of molecular sciences · 2017Review
- Features of Maternal HIV-1 Associated with Lack of Vertical Transmission.The open virology journal · 2017Review
- Molecular mechanisms of HIV-1 mother-to-child transmission and infection in neonatal target cells.Life sciences · 2011Review
- Human immunodeficiency virus type 1 Vpr: oligomerization is an essential feature for its incorporation into virus particles.Virology journal · 2010Article
- Article
- Human immunodeficiency virus infection inhibits granulocyte-macrophage colony-stimulating factor-induced microglial proliferation.Journal of neurovirology · 2007Article
- SIV Vpr evolution is inversely related to disease progression in a morphine-dependent rhesus macaque model of AIDS.Virology · 2007Article
- Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission.Retrovirology · 2006Article
- Molecular characterization of the HIV-1 gag nucleocapsid gene associated with vertical transmission.Retrovirology · 2006Article
- Conservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmission.Retrovirology · 2005Article
- Nuclear export of Vpr is required for efficient replication of human immunodeficiency virus type 1 in tissue macrophages.Journal of virology · 2003Article
- Human immunodeficiency virus type 1 Vpr protein does not modulate surface expression of the CD4 receptor.Journal of virology · 2002Article
- HIV-1 Vpr enhances viral burden by facilitating infection of tissue macrophages but not nondividing CD4+ T cells.The Journal of experimental medicine · 2001Article
- Nucleocytoplasmic shuttling by human immunodeficiency virus type 1 Vpr.Journal of virology · 2001Article
- Human immunodeficiency virus type 1 Vpr contains two leucine-rich helices that mediate glucocorticoid receptor coactivation independently of its effects on G(2) cell cycle arrest.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The vpr sequences from six human immunodeficiency virus type 1 (HIV-1)-infected mother-infant pairs following perinatal transmission were analyzed. We found that 153 of the 166 clones analyzed from uncultured peripheral blood mononuclear cell DNA samples showed a 92.17% frequency of intact vpr open reading frames. There was a low degree of heterogeneity of vpr genes within mothers, within infants, and between epidemiologically linked mother-infant pairs. The distances between vpr sequences were greater in epidemiologically unlinked individuals than in epidemiologically linked mother-infant pairs. Moreover, the infants' sequences displayed patterns similar to those seen in their mothers. The functional domains essential for Vpr activity, including virion incorporation, nuclear import, and cell cycle arrest and differentiation were highly conserved in most of the sequences. Phylogenetic analyses of 166 mother-infant pairs and 195 other available vpr sequences from HIV databases formed distinct clusters for each mother-infant pair and for other vpr sequences and grouped the six mother-infant pairs' sequences with subtype B sequences. A high degree of conservation of intact and functional vpr supports the notion that vpr plays an important role in HIV-1 infection and replication in mother-infant isolates that are involved in perinatal transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.