ArticleJournal of virology1998
p53 protein is a suppressor of papillomavirus DNA amplificational replication.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin.Cancer cell · 2025Article
- The human papillomavirus E7 oncoprotein as a regulator of transcription.Virus research · 2017Review
- Host cell restriction factors that limit transcription and replication of human papillomavirus.Virus research · 2017Review
- Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay.PLoS pathogens · 2017Article
- Review
- Inactivation of p53 rescues the maintenance of high risk HPV DNA genomes deficient in expression of E6.PLoS pathogens · 2013Article
- Roles of p53 in herpes simplex virus 1 replication.Journal of virology · 2013Article
- Human papillomavirus infections: warts or cancer?Cold Spring Harbor perspectives in biology · 2013Review
- HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Robust production and passaging of infectious HPV in squamous epithelium of primary human keratinocytes.Genes & development · 2009Article
- Critical role of p53 in histone deacetylase inhibitor-induced Epstein-Barr virus Zta expression.Journal of virology · 2008Article
- P53 represses human papillomavirus type 16 DNA replication via the viral E2 protein.Virology journal · 2008Article
- Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation.Oncogene · 2003Review
- UVB irradiation reduces the half-life and transactivation potential of the human papillomavirus 16 E2 protein.Oncogene · 2003Article
- Replication of damaged DNA in vitro is blocked by p53.Nucleic acids research · 2003Article
- Induction of the bovine papillomavirus origin "onion skin"-type DNA replication at high E1 protein concentrations in vivo.Journal of virology · 2002Article
- Review
- Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- Cell-specific modulation of papovavirus replication by tumor suppressor protein p53.Journal of virology · 2000Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p53 protein was able to block human and bovine papillomavirus DNA amplificational replication while not interfering with Epstein-Barr virus oriP once-per-cell cycle replication. Oligomerization, intact DNA-binding, replication protein A-binding, and proline-rich domains of the p53 protein were essential for efficient inhibition, while the N-terminal transcriptional activation and C-terminal regulatory domains were dispensable for the suppressor activity of the p53 protein. The inhibition of replication was caused neither by the downregulation of expression of the E1 and E2 proteins nor by cell cycle block or apoptosis. Our data suggest that the intrinsic activity of p53 to suppress amplificational replication of the papillomavirus origin may have an important role in the virus life cycle and in virus-cell interactions.
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Registered trials
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