ArticleJournal of virology1998
A role for herpesvirus saimiri orf14 in transformation and persistent infection.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Endemic Viruses of Squirrel Monkeys (Saimiri spp.).Comparative medicine · 2015Review
- Identification and sequencing of a novel rodent gammaherpesvirus that establishes acute and latent infection in laboratory mice.Journal of virology · 2011Article
- The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivo.Journal of virology · 2010Article
- Viral modulation of T-cell receptor signaling.Journal of virology · 2008Review
- T-cell growth transformation by herpesvirus saimiri is independent of STAT3 activation.Journal of virology · 2005Article
- Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein.Molecular and cellular biology · 2004Article
- Kaposi's sarcoma-associated herpesvirus OX2 glycoprotein activates myeloid-lineage cells to induce inflammatory cytokine production.Journal of virology · 2002Article
- Herpesvirus saimiri.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Independence of herpesvirus-induced T cell lymphoma from viral cyclin D homologue.The Journal of experimental medicine · 2001Article
- Herpesvirus saimiri vFLIP provides an antiapoptotic function but is not essential for viral replication, transformation, or pathogenicity.Journal of virology · 2000Article
- Evolutionary aspects of oncogenic herpesviruses.Molecular pathology : MP · 2000Review
- Analysis of gene expression in a human cell line stably transduced with herpesvirus saimiri.Journal of virology · 2000Article
- Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.Journal of virology · 2000Article
- Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice.Journal of virology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The product of open reading frame 14 (orf14) of herpesvirus saimiri (HVS) exhibits significant homology with mouse mammary tumor virus superantigen. orf14 encodes a 50-kDa secreted glycoprotein, as shown previously (Z. Yao, E. Maraskovsky, M. K. Spriggs, J. I. Cohen, R. J. Armitage, and M. R. Alderson, J. Immunol. 156:3260-3266, 1996). orf14 expressed from recombinant baculovirus powerfully induces proliferation of CD4-positive cells originating from several different species. To study the role of orf14 in transformation, a mutant form of HVS (HVS Deltaorf14) was constructed with a deletion in the orf14 gene. The transforming potential of HVS Deltaorf14 was tested in cell culture and in common marmosets. Parental HVS subgroup C strain 488 immortalized common marmoset T lymphocytes in vitro to interleukin-2-independent growth, while the HVS Deltaorf14 mutant did not produce such a growth transformation. In addition, HVS Deltaorf14 was nononcogenic in common marmosets. In contrast to other nononcogenic HVS mutant viruses which were repeatedly isolated from peripheral blood mononuclear cells of infected marmosets for more than 5 months, HVS Deltaorf14 did not persist at a high level in vivo. These results demonstrate that orf14 of HVS is not required for replication but is required for transformation and for high-level persistence in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.