ArticleJournal of virology1998
Brefeldin A inhibits cell-free, de novo synthesis of poliovirus.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Cell-Free Gene Expression: Methods and Applications.Chemical reviews · 2025Review
- Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback.Cell systems · 2021Article
- Picornaviruses: A View from 3A.Viruses · 2021Review
- Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses.Viruses · 2020Review
- A Redundant Mechanism of Recruitment Underlies the Remarkable Plasticity of the Requirement of Poliovirus Replication for the Cellular ArfGEF GBF1.Journal of virology · 2019Article
- Mx Is Not Responsible for the Antiviral Activity of Interferon-α against Japanese Encephalitis Virus.Viruses · 2017Article
- Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses.Tropical medicine and health · 2017Article
- Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases.The Journal of general virology · 2016Article
- Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles.Trends in microbiology · 2016Review
- Analysis of the interaction between host factor Sam68 and viral elements during foot-and-mouth disease virus infections.Virology journal · 2015Article
- New small-molecule inhibitors effectively blocking picornavirus replication.Journal of virology · 2014Article
- Rewiring of cellular membrane homeostasis by picornaviruses.Journal of virology · 2014Review
- Article
- Oxysterol-binding protein family I is the target of minor enviroxime-like compounds.Journal of virology · 2013Article
- ADP ribosylation factor 1 plays an essential role in the replication of a plant RNA virus.Journal of virology · 2013Article
- Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection.Journal of virology · 2012Article
- Viral subversion of host functions for picornavirus translation and RNA replication.Future virology · 2012Article
- Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity.Journal of virology · 2011Article
- Selective translation of the measles virus nucleocapsid mRNA by la protein.Frontiers in microbiology · 2011Article
- NMR solution structure of poliovirus uridylyated peptide linked to the genome (VPgpU).Peptides · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Brefeldin A (BFA), an inhibitor of intracellular vesicle-dependent secretory transport, is a potent inhibitor of poliovirus RNA replication in infected cells. We have determined that the unknown mechanism of BFA inhibition of replication is reproduced in the cell-free poliovirus translation, replication, and encapsidation system. Furthermore, we provide evidence suggesting that the cellular mechanism targeted by BFA, the GTP-dependent synthesis of secretory transport vesicles, may be involved in viral RNA replication in the system via a soluble cellular GTP-binding and -hydrolyzing activity. This activity is related to the ARF (ADP-ribosylation factor) family of GTP-binding proteins. ARFs are required for the formation of several classes of secretory vesicles, and some family members are indirectly inactivated by BFA. Peptides that function as competitive inhibitors of ARF activity in cell-free transport systems also inhibit poliovirus RNA replication, and this inhibitory effect can be countered by the addition of exogenous ARF. We suggest that BFA inhibition of replication is diagnostic of a requirement for ARF activity in the cell-free system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.