ArticleJournal of virology1998
Characterization of a cis-acting sequence in the Pol region required to transfer human foamy virus vectors.
Article in Journal of virology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Review
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- Review
- Foamy virus assembly with emphasis on pol encapsidation.Viruses · 2013Review
- The prototype foamy virus protease is active independently of the integrase domain.Retrovirology · 2012Article
- Retroviral GAG proteins recruit AGO2 on viral RNAs without affecting RNA accumulation and translation.Nucleic acids research · 2012Article
- Review
- Foamy virus nuclear RNA export is distinct from that of other retroviruses.Journal of virology · 2011Article
- Foamy virus vectors for gene transfer.Expert opinion on biological therapy · 2009Review
- Accuracy estimation of foamy virus genome copying.Retrovirology · 2009Article
- Transduction of human neural progenitor cells with foamy virus vectors for differentiation-dependent gene expression.Gene therapy · 2009Article
- AZT-resistant foamy virus.Virology · 2008Article
- Role of the foamy virus Pol cleavage site in viral replication.Journal of virology · 2007Article
- Foamy virus vector integration sites in normal human cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- RNA and protein requirements for incorporation of the Pol protein into foamy virus particles.Journal of virology · 2005Article
- Role of the C terminus of foamy virus Gag in RNA packaging and Pol expression.Journal of virology · 2004Article
- Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase.Journal of virology · 2004Article
- Retrotransposition and cell-to-cell transfer of foamy viruses.Journal of virology · 2003Article
- Pregenomic RNA is required for efficient incorporation of pol polyprotein into foamy virus capsids.Journal of virology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify cis-acting elements in the foamy virus (FV) RNA pregenome, we developed a transient-vector-production system based on cotransfection of indicator gene-bearing vector and gag-pol and env expression plasmids. Two elements which were critical for vector transfer were found and mapped approximately. The first element was located in the RU5 leader and the 5' gag region (approximately up to position 650 of the viral RNA). The second element was located in an approximately 2-kb sequence in the 3' pol region. Although small 5' and 3' deletions, as well as internal deletions of the latter element, were tolerated, both elements were found to be absolutely required for vector transfer. The functional characterization of the pol region-located cis-acting element revealed that it is essential for efficient incorporation or the stability of particle-associated virion RNA. Furthermore, virions derived from a vector lacking this sequence were found to be deficient in the cleavage of the Gag protein by the Pol precursor protease. Our results suggest that during the formation of infectious virions, complex interactions between FV Gag and Pol and the viral RNA take place.
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