ArticleProceedings of the National Academy of Sciences of the United States of America1998
Activation of epsilon protein kinase C correlates with a cardioprotective effect of regular ethanol consumption.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 104 citations in OpenAlex.
- Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic CaJournal of molecular and cellular cardiology · 2019Article
- The adenosine transporter, ENT1, in cardiomyocytes is sensitive to inhibition by ethanol in a kinase-dependent manner: implications for ethanol-dependent cardioprotection and nucleoside analog drug cytotoxicity.Purinergic signalling · 2014Article
- Cell signaling through protein kinase C oxidation and activation.International journal of molecular sciences · 2012Review
- Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms.Journal of molecular and cellular cardiology · 2012Review
- Epac enhances excitation-transcription coupling in cardiac myocytes.Journal of molecular and cellular cardiology · 2012Article
- Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.Journal of molecular and cellular cardiology · 2010Article
- Focus on: The cardiovascular system: what did we learn from the French (Paradox)?Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2010Review
- PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.Journal of molecular and cellular cardiology · 2009Article
- Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2.Journal of molecular and cellular cardiology · 2009Article
- Ethanol for cardiac ischemia: the role of protein kinase c.Therapeutic advances in cardiovascular disease · 2008Review
- Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach.The pharmacogenomics journal · 2007Article
- Antecedent ethanol ingestion prevents postischemic leukocyte adhesion and P-selectin expression by a protein kinase C-dependent mechanism.Digestive diseases and sciences · 2005Article
- Phospholipase C activation is required for cardioprotection by ethanol consumption.Experimental and clinical cardiology · 2003Article
- Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Animal models in alcohol research.Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism · 2000Review
- Cardioprotection from ischemia by a brief exposure to physiological levels of ethanol: role of epsilon protein kinase C.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In addition to decreasing the incidence of myocardial infarction, recent epidemiological data suggest that regular alcohol consumption improves survival after myocardial infarction. We recently found that chronic ethanol exposure induces long-term protection against cardiac ischemia-reperfusion injury, which improves myocardial recovery after infarction. Furthermore, this cardioprotection by ethanol is mediated through myocyte adenosine A1 receptors. We now determine the role of protein kinase C (PKC) in ethanol's protective effect against ischemia-reperfusion injury. Using perfused hearts of ethanol-fed guinea pigs, we find that improved contractile recovery and creatine kinase release after ischemia-reperfusion are abolished by PKC inhibition with chelerythrine. Western blot analysis and immunofluorescence localization demonstrate that regular ethanol consumption causes sustained translocation (activation) of epsilonPKC, but not delta or alphaPKC. This same isozyme is directly implicated in ischemic preconditioning's protection against ischemia-reperfusion injury. Our findings suggest (i) that regular ethanol consumption induces long-term cardioprotection through sustained translocation of epsilonPKC and (ii) that PKC activity is necessary at the time of ischemia to mediate ethanol's protective effect against ischemia-reperfusion injury. Studying this selective effect of ethanol on epsilonPKC activation may lead to new therapies to protect against ischemia-reperfusion injury in the heart and other organ systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.