ArticleProceedings of the National Academy of Sciences of the United States of America1998
Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 77 citations in OpenAlex.
- Characterization of Acute Myeloid Leukemia With t(16;21) Translocation: Cytogenetic, Molecular, and Immunophenotypic Findings.World journal of oncology · 2026Article
- FUS-ERG induces late-onset azacitidine resistance in acute myeloid leukaemia cells.Scientific reports · 2023Article
- TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review.Annals of hematology · 2022Review
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- Article
- Acute basophilic leukemia associated with the t(16;21)(p11;q22)/Clinical case reports · 2017Article
- miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Article
- Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.Leukemia · 2015Article
- Cryptic FUS-ERG fusion identified by RNA-sequencing in childhood acute myeloid leukemia.Oncology reports · 2013Article
- Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Promiscuous partnerships in Ewing's sarcoma.Cancer genetics · 2011Review
- Relapse of Acute Myeloid Leukemia with t(16;21)(p11;q22) Mimicking Autoimmune Pancreatitis after Second Allogeneic Bone Marrow Transplantation.ISRN hematology · 2011Article
- ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.PloS one · 2011Article
- Primitive origins of prostate cancer: in vivo evidence for prostate-regenerating cells and prostate cancer-initiating cells.Molecular oncology · 2010Review
- The oncogenic role of the ETS transcription factors MEF and ERG.Cell cycle (Georgetown, Tex.) · 2010Review
- Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia.Neurology · 2010Article
- ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction.Methods in molecular biology (Clifton, N.J.) · 2009Article
- Investigating human leukemogenesis: from cell lines to in vivo models of human leukemia.Leukemia · 2008Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Many chimeric oncogenes have been identified by virtue of the association between chromosomal translocation and specific human leukemias. However, the biological mechanism by which these oncogenes disrupt the developmental program of normal human hematopoietic cells during the initiation of the leukemogenic process is poorly understood due to the absence of an appropriate experimental system to study their function. Here, we report that retroviral transduction of TLS-ERG, a myeloid leukemia-associated fusion gene, to human cord blood cells results in altered myeloid and arrested erythroid differentiation and a dramatic increase in the proliferative and self-renewal capacity of transduced myeloid progenitors. Thus, TLS-ERG expression alone induced a leukemogenic program that exhibited similarities to the human disease associated with this translocation. These results provide an experimental examination of the early stages of the human leukemogenic process induced by a single oncogene and establish a paradigm to functionally assay putative leukemogenic genes in normal human hematopoietic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.