ArticleProceedings of the National Academy of Sciences of the United States of America1998
Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 132 citations in OpenAlex.
- Class switched bovine ultralong CDR H3 amplicons versus canonical in immune and non-immune tissues.Immunogenetics · 2026Article
- EndothelialResearch square · 2024Article
- The immune-adjunctive potential of recombinant LAB vector expressing murine IFNλ3 (MuIFNλ3) against Type A Influenza Virus (IAV) infection.Gut pathogens · 2023Article
- A single dominant locus restricts retrovirus replication in YBR/Ei mice.Journal of virology · 2023Article
- Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens.Biochemical Society transactions · 2021Review
- Myeloid cell responsiveness to interferon-gamma is sufficient for initial resistance toCurrent research in immunology · 2020Article
- Direct Antiviral Mechanisms of Interferon-Gamma.Immune network · 2018Review
- Article
- TNF signalling drives expansion of bone marrow CD4+ T cells responsible for HSC exhaustion in experimental visceral leishmaniasis.PLoS pathogens · 2017Article
- B cells responses and cytokine production are regulated by their immune microenvironment.Cytokine · 2015Review
- Long-term functional duration of immune responses to HCV NS3/4A induced by DNA vaccination.Gene therapy · 2014Article
- Critical role of the endogenous interferon ligand-receptors in type I and type II interferons response.Immunology · 2014Article
- STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.Molecular and cellular biology · 2014Article
- Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators.The Journal of experimental medicine · 2013Article
- Article
- Memory CD4+ T cells: fate determination, positive feedback and plasticity.Cellular and molecular life sciences : CMLS · 2012Review
- Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection.PLoS pathogens · 2012Article
- Suppression of collagen-induced arthritis in growth arrest and DNA damage-inducible protein 45β-deficient mice.Arthritis and rheumatism · 2011Article
- Gender specificity of altered human immune cytokine profiles in aging.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Interferon-lambda: a new addition to an old family.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
To study the role of the interferon- (IFN) gammaR2 chain in IFN-gamma signaling and immune function, IFN-gammaR2-deficient mice have been generated and characterized. Cells derived from IFN-gammaR2 -/- mice are unable to activate either JAK/STAT signaling proteins or gene transcription in response to IFN-gamma. The lack of IFN-gamma responsiveness alters IFN-gamma-induced Ig class switching by B cells from these mice. In vitro cultures of T cells demonstrate that the T cells from the IFN-gammaR2 -/- mice have a defect in Th1 cell differentiation. The IFN-gammaR2 (-/-) mice also produce lower amounts of IFN-gamma in response to antigenic challenge. In addition, IFN-gammaR2 -/- mice are defective in contact hypersensitivity and are highly susceptible to infection by Listeria monocytogenes. These results demonstrate that the IFN-gammaR2 is essential for IFN-gamma-mediated immune responses in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.