ArticleProceedings of the National Academy of Sciences of the United States of America1998
The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Who cites it
62 citing papers in PubMed, 240 citations in OpenAlex.
- Article
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- Neurosyphilis is characterized by a compartmentalized and robust neuroimmune response but not by neuronal injury.Med (New York, N.Y.) · 2024Article
- Pleiotropic Role of Rainbow Trout CXCRs in Response to Disease and Environment: Insights from Transcriptional Signatures and Structure Analysis.Biomolecules · 2024Article
- Neuroimmunomodulatory properties of polysialic acid.Glycoconjugate journal · 2023Review
- C-C Chemokine Receptor 7 in Cancer.Cells · 2022Review
- The role of CXCR3 and its ligands in cancer.Frontiers in oncology · 2022Review
- Evolution, Expression and Functional Analysis of CXCR3 in Neuronal and Cardiovascular Diseases: A Narrative Review.Frontiers in cell and developmental biology · 2022Review
- C-X-C Motif Chemokine Ligand 9 and Its CXCR3 Receptor Are the Salt and Pepper for T Cells Trafficking in a Mouse Model of Gaucher Disease.International journal of molecular sciences · 2021Article
- Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway.Redox biology · 2021Article
- In Sickness and in Health: The Immunological Roles of the Lymphatic System.International journal of molecular sciences · 2021Review
- EGFR/Ras-induced CCL20 production modulates the tumour microenvironment.British journal of cancer · 2020Article
- ACKR4 restrains antitumor immunity by regulating CCL21.The Journal of experimental medicine · 2020Article
- Differential role of CXCR3 in inflammation and colorectal cancer.Oncotarget · 2018Review
- Angiodrastic Chemokines in Colorectal Cancer: Clinicopathological Correlations.Analytical cellular pathology (Amsterdam) · 2018Article
- Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring.Advances in wound care · 2015Review
- Low-dose paclitaxel improves the therapeutic efficacy of recombinant adenovirus encoding CCL21 chemokine against murine cancer.Cancer science · 2014Article
- International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.Pharmacological reviews · 2014Review
- The anti-tumor effect and increased tregs infiltration mediated by rAAV-SLC vector.Molecular biology reports · 2013Article
- Human eosinophils express functional CCR7.American journal of respiratory cell and molecular biology · 2013Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine, which binds to a CXC chemokine receptor. Like other ligands of this receptor, 6Ckine has angiostatic properties. 6Ckine is known to chemoattract T cells. In line with this, CXCR3 is expressed preferentially in Th1 cells and in lymphoid organs of the IL-10(-/-) mouse that develops chronic colitis. Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.