ArticleProceedings of the National Academy of Sciences of the United States of America1998
Structural similarities between topoisomerases that cleave one or both DNA strands.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Phytochemical-Based Strategies for Lung Cancer: Clinical Insights Into Pleiotropic Molecular Signaling and Therapeutic Roles.Phytotherapy research : PTR · 2026Review
- Inhibition of DNA cleavage and strand passage activities of Mycobacterium tuberculosis topoisomerase I.Nucleic acids research · 2025Article
- Structural insights into the assembly of type IIA topoisomerase DNA cleavage-religation center.Nucleic acids research · 2024Article
- Insights into the DNA and RNA Interactions of Human Topoisomerase III Beta Using Molecular Dynamics Simulations.Journal of chemical information and modeling · 2024Article
- Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life.Cells · 2024Review
- Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site.Nucleic acids research · 2018Article
- Phenanthriplatin Acts As a Covalent Poison of Topoisomerase II Cleavage Complexes.ACS chemical biology · 2016Article
- Profile of James M. Berger.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Targeting bacterial topoisomerase I to meet the challenge of finding new antibiotics.Future medicinal chemistry · 2015Review
- Mechanism and regulation of meiotic recombination initiation.Cold Spring Harbor perspectives in biology · 2014Review
- DNA topoisomerase II is involved in regulation of cyst wall protein genes and differentiation in Giardia lamblia.PLoS neglected tropical diseases · 2013Article
- Identification of anziaic acid, a lichen depside from Hypotrachyna sp., as a new topoisomerase poison inhibitor.PloS one · 2013Article
- All tangled up: how cells direct, manage and exploit topoisomerase function.Nature reviews. Molecular cell biology · 2011Review
- Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- The use of divalent metal ions by type II topoisomerases.Metallomics : integrated biometal science · 2010Review
- A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.Nature · 2010Article
- Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.Biochemistry · 2009Article
- Effects of magnesium and related divalent metal ions in topoisomerase structure and function.Nucleic acids research · 2009Review
- The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing.Nucleic acids research · 2009Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Type IA and type II DNA topoisomerases are distinguished by their ability to cleave one or two strands, respectively, of a DNA duplex. Both types have been proposed to use an "enzyme-bridging" mechanism, in which a break is formed in a DNA strand and a gap is opened between the broken pieces to allow passage of a second DNA strand or duplex segment. Although the type IA and type II topoisomerase structures appear overall quite different from one another, unexpected similarities between several structural elements suggest that members of the two subfamilies may use comparable mechanisms to bind and cleave DNA.
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