ArticleThe Journal of experimental medicine1998
The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 97 citations in OpenAlex.
- DOT1L activity limits transcription elongation velocity and favors RNAPII pausing to facilitate mutagenesis by AID.Nature communications · 2026Article
- Blunting specific T-dependent antibody responses with engineered "decoy" B cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- The role of CD180 in hematological malignancies and inflammatory disorders.Molecular medicine (Cambridge, Mass.) · 2023Review
- Irradiation Attenuates Systemic Lupus Erythematosus-Like Morbidity in NZBWF1 Mice: Focusing on CD180-Negative Cells.Journal of immunology research · 2023Article
- Discovering immunoreceptor coupling and organization motifs.Frontiers in immunology · 2023Article
- Article
- The Potential Role of RP105 in Regulation of Inflammation and Osteoclastogenesis During Inflammatory Diseases.Frontiers in cell and developmental biology · 2021Review
- CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus.Frontiers in immunology · 2018Article
- Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells.Cellular & molecular immunology · 2017Article
- Chronic Lymphocytic Leukemia: Exploiting Vulnerabilities with Targeted Agents.Current hematologic malignancy reports · 2016Review
- CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk.The EMBO journal · 2015Article
- Rewiring of sIgM-Mediated Intracellular Signaling through the CD180 Toll-like Receptor.Molecular medicine (Cambridge, Mass.) · 2015Article
- The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.Journal of leukocyte biology · 2013Article
- Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory.The Journal of experimental medicine · 2013Article
- FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists.PloS one · 2010Article
- Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation.Nature immunology · 2008Article
- Src family kinases play multiple roles in differentiation of trophoblasts from human term placenta.The Journal of physiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The B cell-specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C beta I/II (PKCbetaI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105-mediated signaling cascade in B cells. We also find that negative regulation of RP-105-mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor-mediated arrest of RP-105-mediated B cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.