ArticleBritish journal of cancer1998
Down-regulation of Fas gene expression in colon cancer is not a result of allelic loss or gene rearrangement.
Article in British journal of cancer, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Lack of association between Fas rs180082 polymorphism and risk of cervical cancer: an update by meta-analysis.BMC medical genetics · 2013Pooled it
- FAS gene expression, prognostic significance and molecular interactions in lung cancer.Frontiers in oncology · 2024Article
- Article
- Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer.International journal of molecular sciences · 2019Review
- Genetic variations in theOncology letters · 2018Article
- Genetic association between CD95 rs2234767 polymorphism and cervical cancer risk: a meta analysis.International journal of clinical and experimental medicine · 2015Article
- FAS-670 gene polymorphism and cervical carcinogenesis risk: A meta-analysis.Biomedical reports · 2013Article
- Functional comparison between genes dysregulated in ulcerative colitis and colorectal carcinoma.PloS one · 2013Article
- Role of apoptosis in disease.Aging · 2012Review
- Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis.Pathology research international · 2011Article
- Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma.Virchows Archiv : an international journal of pathology · 2008Article
- Fas/Fas ligand gene polymorphism in patients with papillary thyroid cancer in the Turkish population.Journal of endocrinological investigation · 2007Article
- Essential role for hematopoietic Fas ligand (FasL) in the suppression of melanoma lung metastasis revealed in bone marrow chimeric mice.Clinical & experimental metastasis · 2004Article
- Multiple and synergistic deregulations of apoptosis-controlling genes in pancreatic carcinoma cells.British journal of cancer · 2003Article
- Article
- Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide.Molecular and cellular biology · 2000Article
- Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma.British journal of cancer · 2000Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of Fas, an apoptosis-inducing receptor, in colonic epithelium is progressively reduced during malignant transformation. We have examined the human Fas gene for loss of heterozygosity (LOH) and gross rearrangements in colon tumours and matched normal mucosa. Polymerase chain reaction (PCR) primers were designed to span a DraI restriction fragment length polymorphic site in the gene. Heterozygosity was detected in normal DNA samples by PCR amplification of the polymorphic site and restriction enzyme digestion. Thirty-eight of 88 patients (43%) with colon carcinomas were informative for the assay, and LOH was detected in 6 of the 38 (16%) corresponding tumours. Tumours from three patients with LOH did not express detectable Fas mRNA, and Fas expression was reduced or absent in 7 of 11 tumours from informative patients without LOH. Southern blotting of tumour DNA samples was used to detect rearrangement of the Fas gene, but no altered hybridization patterns were observed in 64 tumours analysed. These findings indicate that disruption of the Fas gene is not primarily responsible for the loss of Fas protein expression reported in colon cancer. We have also shown that loss of Fas gene transcription is common in these tumours, which may be due to epigenetic gene silencing.
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