ArticleBritish journal of cancer1998
Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast.
Article in British journal of cancer, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 15 citations in OpenAlex.
- Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression.Breast cancer research : BCR · 2001Article
- Alterations of p16-pRb pathway and chromosome locus 9p21-22 in sporadic invasive breast carcinomas.Molecular medicine (Cambridge, Mass.) · 1998Article
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2 authors at 1 institution in 1 country.
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Abstract
Twenty-three cases of ductal carcinoma in situ (DCIS), ten of which had an associated invasive component, were studied for loss of heterozygosity (LOH) of microsatellite markers on chromosome 9p and the results compared with a panel of 20 invasive breast carcinomas. In addition to the gene encoding p16, chromosome 9p is also thought to contain other putative tumour-suppressor genes. If the three panels of breast tumours showed LOH of markers in this region this would suggest that such putative genes were important in breast carcinogenesis. By studying both preinvasive and invasive breast tumours, it should also be possible to gain further information about the relationship between lesions of a different stage and to determine whether DCIS is indeed a precursor of invasive ductal carcinoma. Levels of LOH were low in the invasive-only set of tumours. Surprisingly, considerably higher levels of loss were observed in the tumours with an in situ component. Also, much heterogeneity was observed between different DCIS ducts or invasive tumour and DCIS from the same case.
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