ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia and hindbrain of the chick embryo: markers of patterned connectivity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 79 citations in OpenAlex.
- Whole-body single-cell atlas of an adult vertebrate in homeostasis and regeneration.bioRxiv : the preprint server for biology · 2026Article
- From neural crest migration to the onset of gangliogenesis.Current topics in developmental biology · 2025Review
- TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism.iScience · 2024Article
- Tlx3 mediates neuronal differentiation and proper condensation of the developing trigeminal ganglion.Developmental biology · 2024Article
- Mapping oto-pharyngeal development in a human inner ear organoid model.Development (Cambridge, England) · 2023Article
- Immunogenetic losses co-occurred with seahorse male pregnancy and mutation in tlx1 accompanied functional asplenia.Nature communications · 2022Article
- Axonal Projection Patterns of the Dorsal Interneuron Populations in the Embryonic Hindbrain.Frontiers in neuroanatomy · 2021Review
- Molecular Events Controlling Cessation of Trunk Neural Crest Migration and Onset of Differentiation.Frontiers in cell and developmental biology · 2020Article
- A V0 core neuronal circuit for inspiration.Nature communications · 2017Article
- Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.PloS one · 2015Article
- Article
- Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Mapping the face in the somatosensory brainstem.Nature reviews. Neuroscience · 2010Review
- Conservation of gene linkage in dispersed vertebrate NK homeobox clusters.Development genes and evolution · 2009Article
- Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates.BMC evolutionary biology · 2008Article
- Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Expression of the neurogenic basic helix-loop-helix transcription factor NEUROG1 identifies a subgroup of medulloblastomas not expressing ATOH1.Neuro-oncology · 2007Article
- Ancient connection between NKL genes and the mesoderm? Insights from Tlx expression in a ctenophore.Development genes and evolution · 2007Article
- Conservation and phylogeny of a novel family of non-Hox genes of the Antp class in Demospongiae (porifera).Journal of molecular evolution · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence suggests that in vertebrates the formation of distinct neuronal cell types is controlled by specific families of homeodomain transcription factors. Furthermore, the expression domains of a number of these genes correlates with functionally integrated neuronal populations. We have isolated two members of the divergent T-cell leukemia translocation (HOX11/Tlx) homeobox gene family from chick, Tlx-1 and Tlx-3, and show that they are expressed in differentiating neurons of both the peripheral and central nervous systems. In the peripheral nervous system, Tlx-1 and Tlx-3 are expressed in overlapping domains within the placodally derived components of a number of cranial sensory ganglia. Tlx-3, unlike Tlx-1, is also expressed in neural crest-derived dorsal root and sympathetic ganglia. In the CNS, both genes are expressed in longitudinal columns of neurons at specific dorsoventral levels of the hindbrain. Each column has distinct anterior and/or posterior limits that respect inter-rhombomeric boundaries. Tlx-3 is also expressed in D2 and D3 neurons of the spinal cord. Tlx-1 and Tlx-3 expression patterns within the peripheral and central nervous systems suggest that Tlx proteins may be involved not only in the differentiation and/or survival of specific neuronal populations but also in the establishment of neuronal circuitry. Furthermore, by analogy with the LIM genes, Tlx family members potentially define sensory columns early within the developing hindbrain in a combinatorial manner.
Indexed as
Identifiers
9651221PMC6793508W2096665544What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.