The sodium channel Scn8a is the major contributor to the postnatal developmental increase of sodium current density in spinal motoneurons.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

17 citing papers in PubMed, 55 citations in OpenAlex.

1. Age-dependent reduction in voltage-gated inward sodium current and Scn8a gene expression in murine stellate ganglia.Annals of the New York Academy of Sciences · 2025
   Article
2. Distinctive Properties and Powerful Neuromodulation of NaCells · 2021
   Review
3. Trafficking mechanisms underlying NaChannels (Austin, Tex.) · 2020
   Review
4. Rapid evolution of a voltage-gated sodium channel gene in a lineage of electric fish leads to a persistent sodium current.PLoS biology · 2018
   Article
5. Current injection and receptor-mediated excitation produce similar maximal firing rates in hypoglossal motoneurons.Journal of neurophysiology · 2016
   Article
6. Prioritizing the development of mouse models for childhood brain disorders.Neuropharmacology · 2016
   Review
7. Developing electrical properties of postnatal mouse lumbar motoneurons.Frontiers in cellular neuroscience · 2015
   Article
8. Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.The Journal of biological chemistry · 2010
   Article
9. Analysis of the mouse mutant Cloth-ears shows a role for the voltage-gated sodium channel Scn8a in peripheral neural hearing loss.Genes, brain, and behavior · 2009
   Article
10. The roles of sodium channels in nociception: Implications for mechanisms of pain.Pain · 2007
    Review
11. The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003
    Article
12. Molecular determinants of emerging excitability in rat embryonic motoneurons.The Journal of physiology · 2002
    Article
13. Transcriptional channelopathies: an emerging class of disorders.Nature reviews. Neuroscience · 2001
    Review
14. Channelopathies: ion channel defects linked to heritable clinical disorders.Journal of medical genetics · 2000
    Review
15. Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.Biophysical journal · 2000
    Article
16. Functional analysis of the mouse Scn8a sodium channel.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998
    Article
17. Chronic, Episodic Nicotine Alters Hypoglossal Motor Neuron Function at a Critical Developmental Time Point in Neonatal Rats.eNeuro
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

4 authors at 2 institutions in 1 country.

Funding

Abstract

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