ArticleGenetics1998
Correlation between the substitution rate and rate variation among sites in protein evolution.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Genome-wide analysis reveals the contributors to fast molecular evolution of the Chinese hook snout carp (Computational and structural biotechnology journal · 2024Article
- Transposon insertional mutagenesis of diverse yeast strains suggests coordinated gene essentiality polymorphisms.Nature communications · 2022Article
- Are Nonsynonymous Transversions Generally More Deleterious than Nonsynonymous Transitions?Molecular biology and evolution · 2021Article
- Protein Complexes Form a Basis for Complex Hybrid Incompatibility.Frontiers in genetics · 2021Review
- Non-Markovian effects on protein sequence evolution due to site dependent substitution rates.BMC bioinformatics · 2016Article
- Determinants of the rate of protein sequence evolution.Nature reviews. Genetics · 2015Review
- Phylostratigraphic bias creates spurious patterns of genome evolution.Molecular biology and evolution · 2015Article
- Biophysical and structural considerations for protein sequence evolution.BMC evolutionary biology · 2011Article
- Parameters of proteome evolution from histograms of amino-acid sequence identities of paralogous proteins.Biology direct · 2007Article
- Estimating the number of ancestral lineages using a maximum-likelihood method based on rejection sampling.Genetics · 2007Article
- Inferring the demographic history and rate of adaptive substitution in Drosophila.PLoS genetics · 2006Article
- UVPAR: fast detection of functional shifts in duplicate genes.BMC bioinformatics · 2006Article
- Rapid nonsynonymous evolution of the iron-sulfur protein in anthropoid primates.Journal of bioenergetics and biomembranes · 2005Article
- Genetic diversity and population history of golden monkeys (Rhinopithecus roxellana).Genetics · 2003Article
- A methodological bias toward overestimation of molecular evolutionary time scales.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Genomic biodiversity, phylogenetics and coevolution in proteins.Applied bioinformatics · 2002Review
- Erratic overdispersion of three molecular clocks: GPDH, SOD, and XDH.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Estimation of divergence times from multiprotein sequences for a few mammalian species and several distantly related organisms.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- From complete genomes to measures of substitution rate variability within and between proteins.Genome research · 2000Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that the rate of amino acid substitution varies among different proteins and among different sites of a protein. It is, however, unclear whether the extent of rate variation among sites of a protein and the mean substitution rate of the protein are correlated. We used two approaches to analyze orthologous protein sequences of 51 nuclear genes of vertebrates and 13 mitochondrial genes of mammals. In the first approach, no assumptions of the distribution of the rate variation among sites were made, and in the second approach, the gamma distribution was assumed. Through both approaches, we found a negative correlation between the extent of among-site rate variation and the average substitution rate of a protein. That is, slowly evolving proteins tend to have a high level of rate variation among sites, and vice versa. We found this observation consistent with a simple model of the neutral theory where most sites are either invariable or neutral. We conclude that the correlation is a general feature of protein evolution and discuss its implications in statistical tests of positive Darwinian selection and molecular time estimation of deep divergences.
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