ArticleGenetics1998
Courtship and visual defects of cacophony mutants reveal functional complexity of a calcium-channel alpha1 subunit in Drosophila.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 91 citations in OpenAlex.
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- Parasite manipulation of host phenotypes inferred from transcriptional analyses in a trematode-amphipod system.Molecular ecology · 2023Article
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- Homeostatic Depression Shows Heightened Sensitivity to Synaptic Calcium.Frontiers in cellular neuroscience · 2021Article
- Regulation of Metabolism by an Ensemble of Different Ion Channel Types: Excitation-Secretion Coupling Mechanisms of Adipokinetic Hormone Producing Cells inFrontiers in physiology · 2020Article
- Calmodulin-binding transcription factor shapes the male courtship song in Drosophila.PLoS genetics · 2019Article
- Endogenous Tagging Reveals Differential Regulation of CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Regulation of gene expression and RNA editing in Drosophila adapting to divergent microclimates.Nature communications · 2017Article
- Article
- C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.PLoS genetics · 2016Article
- Mutations of the Calcium Channel Gene cacophony Suppress Seizures in Drosophila.PLoS genetics · 2016Article
- Article
- A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticity.Frontiers in cellular neuroscience · 2015Article
- Homeostatic plasticity at the Drosophila neuromuscular junction.Neuropharmacology · 2014Review
- How voltage-gated calcium channels gate forms of homeostatic synaptic plasticity.Frontiers in cellular neuroscience · 2014Review
- When population and evolutionary genetics met behaviour.Memorias do Instituto Oswaldo Cruz · 2013Review
- Transsynaptic control of presynaptic Ca²⁺ influx achieves homeostatic potentiation of neurotransmitter release.Current biology : CB · 2012Article
- Transcriptomic profiling of central nervous system regions in three species of honey bee during dance communication behavior.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We show by molecular analysis of behavioral and physiological mutants that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and physiological phenotypes associated with this gene. The cacS mutant, which exhibits defects in the patterning of courtship lovesong and a newly revealed but subtle abnormality in visual physiology, is mutated such that a highly conserved phenylalanine (in one of the quasi-homologous intrapolypeptide regions called IIIS6) is replaced by isoleucine. The cacH18 mutant exhibits defects in visual physiology (including complete unresponsiveness to light in certain genetic combinations) and visually mediated behaviors; this mutant (originally nbAH18) has a stop codon in an alternative exon (within the cac ORF), which is differentially expressed in the eye. Analysis of the various courtship and visual phenotypes associated with this array of cac mutants demonstrates that Dmca1A calcium channels mediate multiple, separable biological functions; these correlate in part with transcript diversity generated via alternative splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.