ArticleGenetics1998
The M26 hotspot of Schizosaccharomyces pombe stimulates meiotic ectopic recombination and chromosomal rearrangements.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Proliferation and dissemination of killer meiotic drive loci.Current opinion in genetics & development · 2023Review
- Analysis of piRNA-mediated silencing of active TEs in Drosophila melanogaster suggests limits on the evolution of host genome defense.Molecular biology and evolution · 2013Article
- Nucleosomal organization of replication origins and meiotic recombination hotspots in fission yeast.The EMBO journal · 2012Article
- Meiotic Recombination in Schizosaccharomyces pombe: A Paradigm for Genetic and Molecular Analysis.Genome dynamics and stability · 2008Article
- Effects of recombination rate on human endogenous retrovirus fixation and persistence.Journal of virology · 2007Article
- The meiotic bouquet promotes homolog interactions and restricts ectopic recombination in Schizosaccharomyces pombe.Genetics · 2006Article
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- Compartmentalization of the yeast meiotic nucleus revealed by analysis of ectopic recombination.Genetics · 2004Article
- Effects of recombination rate and gene density on transposable element distributions in Arabidopsis thaliana.Genome research · 2003Article
- Recombination rate and the distribution of transposable elements in the Drosophila melanogaster genome.Genome research · 2002Article
- Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe.Proceedings of the National Academy of Sciences of the United States of America · 2001Review
- A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination.The EMBO journal · 2001Article
- Crossing over is rarely associated with mitotic intragenic recombination in Schizosaccharomyces pombe.Genetics · 2001Article
- Restriction of ectopic recombination by interhomolog interactions during Saccharomyces cerevisiae meiosis.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Telomere-led bouquet formation facilitates homologous chromosome pairing and restricts ectopic interaction in fission yeast meiosis.The EMBO journal · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homologous recombination is increased during meiosis between DNA sequences at the same chromosomal position (allelic recombination) and at different chromosomal positions (ectopic recombination). Recombination hotspots are important elements in controlling meiotic allelic recombination. We have used artificially dispersed copies of the ade6 gene in Schizosaccharomyces pombe to study hotspot activity in meiotic ectopic recombination. Ectopic recombination was reduced 10-1000-fold relative to allelic recombination, and was similar to the low frequency of ectopic recombination between naturally repeated sequences in S. pombe. The M26 hotspot was active in ectopic recombination in some, but not all, integration sites, with the same pattern of activity and inactivity in ectopic and allelic recombination. Crossing over in ectopic recombination, resulting in chromosomal rearrangements, was associated with 35-60% of recombination events and was stimulated 12-fold by M26. These results suggest overlap in the mechanisms of ectopic and allelic recombination and indicate that hotspots can stimulate chromosomal rearrangements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.