ArticleGenetics1998
Salmonella virulence plasmid. Modular acquisition of the spv virulence region by an F-plasmid in Salmonella enterica subspecies I and insertion into the chromosome of subspecies II, IIIa, IV and VII isolates.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 99 citations in OpenAlex.
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- Public health data collected by PulseNet support a role forMicrobiology spectrum · 2026Article
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- FinO/ProQ-family proteins: an evolutionary perspective.Bioscience reports · 2023Review
- The Number and Type of Chaperone-Usher Fimbriae Reflect Phylogenetic Clade Rather than Host Range in Salmonella.mSystems · 2022Review
- Whole genome sequencing and protein structure analyses of target genes for the detection of Salmonella.Scientific reports · 2021Article
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- Phylogeny ofMicrobial genomics · 2021Article
- The Role of theFrontiers in microbiology · 2020Article
- Transferable Plasmids ofFrontiers in microbiology · 2020Review
- Embracing Diversity: Differences in Virulence Mechanisms, Disease Severity, and Host Adaptations Contribute to the Success of NontyphoidalFrontiers in microbiology · 2019Review
- The Salmonella type III effector SpvC triggers the reverse transmigration of infected cells into the bloodstream.PloS one · 2019Article
- Antimicrobial Resistance Genes, Cassettes, and Plasmids Present inFrontiers in microbiology · 2019Article
- Going around in circles: virulence plasmids in enteric pathogens.Nature reviews. Microbiology · 2018Review
- rpoS-Regulated core genes involved in the competitive fitness of Salmonella enterica Serovar Kentucky in the intestines of chickens.Applied and environmental microbiology · 2015Article
- The Salmonella effector protein SpvC, a phosphothreonine lyase is functional in plant cells.Frontiers in microbiology · 2014Article
- The role of TcdB and TccC subunits in secretion of the Photorhabdus Tcd toxin complex.PLoS pathogens · 2013Article
- Evolutionary, ecological and biotechnological perspectives on plasmids resident in the human gut mobile metagenome.Bioengineered bugs · 2012Review
- The ecology of bacterial genes and the survival of the new.International journal of evolutionary biology · 2012Article
- The Role of the spv Genes in Salmonella Pathogenesis.Frontiers in microbiology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The spv operon is common to all Salmonella virulence plasmids. DNA hybridization analysis indicates that the spv region is limited in distribution to serovars of Salmonella enterica subspecies I, II, IIIa, IV, and VII and is absent from Salmonella bongori isolates. Among strains of subspecies II, IIIa, and VII, all isolates examined contained sequences that hybridized with the spv region. However, among isolates of subspecies I, DNA sequences capable of hybridizing with the spv region were found in some isolates of certain serovars. Furthermore, in isolates of subspecies I, the virulence plasmid was found in the same set of isolates as an F-related plasmid, as determined by the presence of the spv region of the virulence plasmid and the finO, traD, and repA sequences of the F-plasmid. The concordance of the virulence plasmid and all three F-plasmid sequences in subspecies I serovar Choleraesuis, Paratyphi, and Typhimurium is most easily explained if the spv region is carried in an F-related plasmid in these isolates. In contrast, among S. enterica subspecies II, IIIa, IV, and VII, the isolates that contain spv sequences did not hybridize with an F-related plasmid or any other identifiable plasmid. With the use of pulse-field gel electrophoresis, the spv region in subspecies II, IIIa, and VII was found to be encoded on the chromosome. Analysis of the phylogenetic distribution of spv among Salmonella isolates and comparative nucleotide sequence analysis of spvA and spvC suggests that the spv region was acquired very recently, after speciation of the salmonellae.
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