ArticleThe EMBO journal1998
Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed.
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- High-Salt Diet Accelerates Neuron Loss and Anxiety inInternational journal of molecular sciences · 2024Article
- Stress-induced microautophagy is coordinated with lysosome biogenesis and regulated by PIKfyve.Molecular biology of the cell · 2024Article
- The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism.Autophagy · 2023Article
- Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy.International journal of molecular sciences · 2021Review
- Astaxanthin Inhibits Autophagic Cell Death Induced by Bisphenol A in Human Dermal Fibroblasts.Antioxidants (Basel, Switzerland) · 2021Article
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- Disruption of Endoplasmic Reticulum and ROS Production in Human Ovarian Cancer by Campesterol.Antioxidants (Basel, Switzerland) · 2021Article
- Mitophagy in the Pathogenesis of Liver Diseases.Cells · 2020Review
- Autophagy and autophagy-related proteins in cancer.Molecular cancer · 2020Review
- History of the Selective Autophagy Research: How Did It Begin and Where Does It Stand Today?Journal of molecular biology · 2020Review
- Activation and targeting of ATG8 protein lipidation.Cell discovery · 2020Review
- Biological functions of the autophagy-related proteins Atg4 and Atg8 in Cryptococcus neoformans.PloS one · 2020Article
- Role of Autophagy Biomarkers In Burn-Age Estimation and Progression.Academic forensic pathology · 2019Article
- Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins.The Journal of biological chemistry · 2019Article
- Diverse Functions of Autophagy in Liver Physiology and Liver Diseases.International journal of molecular sciences · 2019Review
- The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions.International journal of molecular sciences · 2018Review
- Life, death and autophagy.Nature cell biology · 2018Review
- New insight into the mechanism underlying the silk gland biological process by knocking out fibroin heavy chain in the silkworm.BMC genomics · 2018Article
- Autophagic Induction Greatly EnhancesFrontiers in microbiology · 2018Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AUT2 and AUT7, two novel genes essential for autophagocytosis in the yeast Saccharomyces cerevisiae were isolated. AUT7 was identified as a low copy suppressor of autophagic defects in aut2-1 cells. Aut7p is a homologue of the rat microtubule-associated protein (MAP) light chain 3 (LC3). Aut2p and Aut7p interact physically. Aut7p is attached to microtubules via Aut2p, which interacts with tubulins Tub1p and Tub2p. aut2- and aut7-deleted cells are unable to deliver autophagic vesicles and the precursor of aminopeptidase I to the vacuole. Double membrane-layered autophagosome-like vesicles accumulate in the cytoplasm of these cells. Our findings suggest that microtubules and an attached protein complex of Aut2p and Aut7p are involved in the delivery of autophagic vesicles to the vacuole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.