ArticleBiophysical journal1998
Material property characteristics for lipid bilayers containing lysolipid.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Membrane Perturbations and Assay Interferences by Ivermectin Explain Its In Vitro SARS-CoV-2 Antiviral Activities and Lack of Translatability.Journal of medicinal chemistry · 2025Review
- Mitochondrial alterations induced by Macrovipera lebetina venom.European biophysics journal : EBJ · 2025Article
- Investigating How Lysophosphatidylcholine and Lysophosphatidylethanolamine Enhance the Membrane Permeabilization Efficacy of Host Defense Peptide Piscidin 1.The journal of physical chemistry. B · 2025Article
- The Effect of Lysophospholipids and Sex on Growth Performance and Small Intestine Morphology in Weanling Pigs, 7-30 kg.Animals : an open access journal from MDPI · 2024Article
- Intrinsic Lipid Curvature and Bilayer Elasticity as Regulators of Channel Function: A Comparative Single-Molecule Study.International journal of molecular sciences · 2024Article
- Preparation and biomedical applications of artificial cells.Materials today. Bio · 2023Review
- Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function.The Journal of general physiology · 2023Article
- Initiation and evolution of pores formed by influenza fusion peptides probed by lysolipid inclusion.Biophysical journal · 2023Article
- Membrane tension controls the phase equilibrium in fusogenic liposomes.RSC advances · 2022Article
- Regulation of Gramicidin Channel Function Solely by Changes in Lipid Intrinsic Curvature.Frontiers in physiology · 2022Article
- Mechanisms underlying drug-mediated regulation of membrane protein function.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Antidepressants are modifiers of lipid bilayer properties.The Journal of general physiology · 2019Article
- Fluorinated Alcohols' Effects on Lipid Bilayer Properties.Biophysical journal · 2018Article
- Frontiers of Complex Disease Mechanisms: Membrane Surface Tension May Link Genotype to Phenotype in Glaucoma.Frontiers in cell and developmental biology · 2018Article
- Divergent effects of anesthetics on lipid bilayer properties and sodium channel function.European biophysics journal : EBJ · 2017Review
- Effect of Statins on the Nanomechanical Properties of Supported Lipid Bilayers.Biophysical journal · 2016Article
- Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come.Pharmacological reviews · 2016Review
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- A general mechanism for drug promiscuity: Studies with amiodarone and other antiarrhythmics.The Journal of general physiology · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The apparent area expansion modulus and tensile strength of egg phosphatidylcholine (EPC) membranes are measured in the presence of monooleoylphosphatidylcholine (MOPC). The apparent area expansion modulus decreases from 171 mN m-1 for pure EPC membrane to 82 mN m-1 for a membrane containing 30 mol % MOPC. This significant decrease of the apparent area expansion modulus is attributed to the change of the membrane area due to the tension-dependent exchange of MOPC between the bathing solution and the membrane. Similar to the apparent area expansion modulus, the tensile strength of the membrane decreases with the increase of the molar concentration of MOPC in the membrane. The tensile strength of pure EPC membrane is 9.4 mN m-1 whereas that for a membrane containing 30 mol % MOPC is only 1.8 mN m-1, and for a membrane containing 50 mol % MOPC it is even smaller, on the order of 0.07 mN m-1. The decrease of the tensile strength is coupled with a decrease of the work for membrane breakdown, which changes from 4.3 x 10(-2) kT for pure EPC membrane to 2 x 10(-6) kT for a membrane with 50 mol % MOPC. Overall, these results show that the decrease of the apparent area expansion modulus in the presence of exchangeable molecules is a fundamental property for all membranes and depends on the area occupied by these molecules. The method presented here provides a unique tool for measuring the area occupied by an exchangeable molecule in the bilayer membrane.
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