ArticleClinical and experimental immunology1998
Colonic explant production of IL-1and its receptor antagonist is imbalanced in inflammatory bowel disease (IBD).
Article in Clinical and experimental immunology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 86 citations in OpenAlex.
- Adacolumn selective leukocyte adsorption apheresis in patients with active ulcerative colitis: clinical efficacy, effects on plasma IL-8, and expression of Toll-like receptor 2 on granulocytes.Digestive diseases and sciences · 2007Trial
- Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis.World journal of gastroenterology · 2006Trial
- Article
- Differential Effect of Dietary Fibers in Intestinal Health of Growing Pigs: Outcomes in the Gut Microbiota and Immune-Related Indexes.Frontiers in microbiology · 2022Article
- A Novel Fusion of IL-10 Engineered to Traffic across Intestinal Epithelium to Treat Colitis.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1Mediators of inflammation · 2020Article
- A modified cholera toxin B subunit containing an ER retention motif enhances colon epithelial repairFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn's disease-related perianal fistula.World journal of gastrointestinal pathophysiology · 2019Article
- Nanomedicines for the Delivery of Biologics.Pharmaceutics · 2019Article
- Curcumin and resveratrol suppress dextran sulfate sodium‑induced colitis in mice.Molecular medicine reports · 2019Article
- Metformin exerts anti-inflammatory effects on mouse colon smooth muscle cells in vitro.Experimental and therapeutic medicine · 2018Article
- Glucagon-like peptide-1 exerts anti-inflammatory effects on mouse colon smooth muscle cells through the cyclic adenosine monophosphate/nuclear factor-κB pathway in vitro.Journal of inflammation research · 2018Article
- Prognostic value of assessment of stool and serum IL-1β, IL-1ra and IL-6 concentrations in children with active and inactive ulcerative colitis.Archives of medical science : AMS · 2018Article
- Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice.Experimental and therapeutic medicine · 2017Article
- Resveratrol raisesThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2015Article
- Protective Effect of Calculus Bovis Sativus on Dextran Sulphate Sodium-Induced Ulcerative Colitis in Mice.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice.Experimental and therapeutic medicine · 2014Article
- Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets.Antioxidants & redox signaling · 2013Review
- Natural products as a source of anti-inflammatory agents associated with inflammatory bowel disease.Molecules (Basel, Switzerland) · 2013Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IBD is associated with an increased activation of intestinal immune cells, which causes overproduction of proinflammatory cytokines such as IL-1beta. IL-1beta is implicated in mediating the sustained inflammatory response. IL-1 receptor antagonist (IL-1Ra), the naturally occurring inhibitor of IL-1, has been shown to have beneficial effects in experimental models of colitis. In this study we investigated the hypothesis that an imbalance between IL-1 and IL-1Ra exists in IBD by measuring their secretion by explant cultures of colonic biopsies. Freshly homogenized biopsies from involved tissue in IBD patients exhibited significantly lower IL-1Ra/IL-1beta ratios than control and uninvolved IBD mucosal tissue. Using explant cultures, in vitro production of IL-1beta and IL-1Ra increased progressively during the 4-18-h culture periods. IL-1beta secretion was higher in supernatants from involved Crohn's disease (CD) and ulcerative colitis tissue compared with control tissue, and IL-1beta levels increased with severity of inflammation. IL-1Ra secretion was not elevated in involved IBD samples, but significantly higher levels were released when moderate to severely involved tissue samples were compared with noninflammatory controls. Similar to freshly homogenized tissue, explant studies showed that the IL-1Ra/IL-1beta ratios were significantly decreased in involved IBD tissue, but not in uninvolved CD or inflammatory control specimens. These data support the hypothesis of an imbalance between IL-1beta and IL-1Ra in IBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.