ArticleGenome research1998
Chicken microchromosomes are hyperacetylated, early replicating, and gene rich.
Article in Genome research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 117 citations in OpenAlex.
- De novo assembly at Chromosomal level of the Indigenous Venda chicken.Scientific data · 2026Article
- Decoding the Avian Missing Gene Mystery: Dot Chromosomes Unmask Extensive Gene Loss and Novel Genetic Instability.Genome biology and evolution · 2026Article
- MicroFinder: conserved gene-set mapping and assembly ordering for manual curation of bird dot microchromosomes.GigaScience · 2026Article
- Review
- Article
- High Chromosomal Reorganization and Presence of Microchromosomes in Chactidae Scorpions from the Brazilian Amazon.Biology · 2023Article
- The gyrfalcon (Falco rusticolus) genome.G3 (Bethesda, Md.) · 2023Article
- Evolutionary analysis of a complete chicken genome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Identification of Iguania Ancestral Syntenic Blocks and Putative Sex Chromosomes in the Veiled Chameleon (International journal of molecular sciences · 2022Article
- Microchromosomes are building blocks of bird, reptile, and mammal chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Why Do Some Vertebrates Have Microchromosomes?Cells · 2021Review
- Article
- DNA Organization along Pachytene Chromosome Axes and Its Relationship with Crossover Frequencies.International journal of molecular sciences · 2021Article
- Patterns of microchromosome organization remain highly conserved throughout avian evolution.Chromosoma · 2019Article
- Together But Different: The Subgenomes of the BimodalFrontiers in plant science · 2019Article
- A dual transcript-discovery approach to improve the delimitation of gene features from RNA-seq data in the chicken model.Biology open · 2018Article
- Review
- Whole-genome sequence-based genomic prediction in laying chickens with different genomic relationship matrices to account for genetic architecture.Genetics, selection, evolution : GSE · 2017Article
- High-throughput and Cost-effective Chicken Genotyping Using Next-Generation Sequencing.Scientific reports · 2016Article
- The chicken erythrocyte epigenome.Epigenetics & chromatin · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chicken karyotype consists of 39 chromosomes of which 33 are classed as microchromosomes (MICs). MICs contain about one third of genomic DNA. The majority of mapped chicken genes are assigned to macrochromosomes (MACs), but a recent study indicated that CpG islands (CGIs), which are associated with most vertebrate genes, map predominantly to MICs. The present work establishes that chicken genes are concentrated on MICs by several criteria. Acetylated (lysine 5) histone H4, which is strongly correlated with the presence of genes, is highly enriched on MICs by immunocytochemistry. In addition, detailed analysis of chicken cosmids shows that CGI-like fragments are approximately six times denser on MICs than on MACs. Published mapping of randomly chosen genes by fluorescent in situ hybridization (FISH) also shows a significant excess of microchromosomal assignments. Finally, the finding that MICs replicate during the first half of S phase is also compatible with the suggestion that MICs represent gene-rich DNA. We use the cosmid data to predict that approximately 75% of chicken genes are located on microchromosomes. [The sequence data described in this paper have been submitted to the GenBank data library under accession nos. AJ001643 and AJ001644.]
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.