ArticleGenome research1998
Evidence for the presence of insulin-dependent diabetes-associated alleles on the distal part of mouse chromosome 6.
Article in Genome research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 48 citations in OpenAlex.
- Article
- Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity.BMC medical genomics · 2009Article
- Article
- Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- B cell inhibitory receptors and autoimmunity.Immunology · 2003Review
- Genetic control of innate immune responses against cytomegalovirus: MCMV meets its match.Genes and immunity · 2002Review
- Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.Genome research · 2000Article
- Age and sex based genetic locus heterogeneity in type 1 diabetes.Journal of medical genetics · 2000Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 1 diabetes (IDDM) is a complex disorder with multifactorial and polygenic etiology. A genome-wide screen performed in a BC1 cohort of a cross between the nonobese diabetic (NOD) mouse with the diabetes-resistant feral strain PWK detected a major locus contributing to diabetes development on the distal part of chromosome 6. Unlike the majority of other Idd loci identified in intraspecific crosses, susceptibility is associated with the presence of the PWK allele. Genetic linkage analysis of congenic lines segregating PWK chromosome 6 segments in a NOD background confirmed the presence of the Idd locus within this region. The genetic interval defined by analysis of congenic animals showed a peak of significant linkage (P = 0.0005) centered on an approximately 9-cM region lying between D6Mit11 and D6Mit25 genetic markers within distal mouse chromosome 6. [Genetic markers polymorphic between the NOD and PWK strains are available as a supplement at http://www.genome.org]
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.