ArticleJournal of medical genetics1998
Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.
Article in Journal of medical genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 212 citations in OpenAlex.
- Pooled it
- Association between promoter polymorphisms of interleukin-4 gene and allergic rhinitis risk: a meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Pooled it
- Unraveling the Pathogenesis of Asian Atopic Dermatitis: Key Characteristics and Insights.Annals of dermatology · 2025Review
- The influence of immune system-related genes on the development of atopic dermatitis.Postepy dermatologii i alergologii · 2025Review
- Overview of Atopic Dermatitis in Different Ethnic Groups.Journal of clinical medicine · 2023Review
- Food Allergy: Searching for the Modern Environmental Culprit.The Yale journal of biology and medicine · 2020Review
- Association analysis of non-synonymous polymorphisms of interleukin-4 receptor-α and interleukin-13 genes in canine atopic dermatitis.The Journal of veterinary medical science · 2020Article
- Interleukin-4 and Interleukin-13 Gene Polymorphisms in Children With Idiopathic Nephrotic Syndrome.Frontiers in pediatrics · 2020Article
- Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis.Science translational medicine · 2019Article
- C-590T Promoter Polymorphism of the Interleukin (IL)-4 Gene Is Associated with an Increased usceptibility to Nasal Polyposis.Reports of biochemistry & molecular biology · 2019Article
- Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci.The Journal of allergy and clinical immunology · 2018Article
- The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.Clinical reviews in allergy & immunology · 2016Review
- Transplantation of human skin microbiota in models of atopic dermatitis.JCI insight · 2016Article
- Genetic and epigenetic studies of atopic dermatitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2016Review
- IL-4 Gene Polymorphism May Contribute to an Increased Risk of Atopic Dermatitis in Children.Disease markers · 2016Article
- Probiotics and Atopic Dermatitis: An Overview.Frontiers in microbiology · 2016Review
- The role of the skin microbiome in atopic dermatitis.Current allergy and asthma reports · 2015Review
- Molecular biology of atopic dermatitis.Clinical reviews in allergy & immunology · 2014Review
- Genetic variations of cytokines and cytokine receptors in psoriasis patients from china.International journal of genomics · 2014Article
- Th2 Cytokines and Atopic Dermatitis.Journal of clinical & cellular immunology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined linkage between markers at and near the IL4 gene and atopic dermatitis (AD) in 88 Japanese nuclear families. Affected sib pair analysis suggested linkage between the IL4 gene and AD (SPLINK lod=2.28). Transmission disequilibrium testing showed a significantly preferential transmission to AD offspring of the T allele of the -590C/T polymorphism of the IL4 gene (p=0.001). A case-control comparison suggested a genotypic association of the TT genotype with AD (odds ratio=1.88, p=0.01). Since the T allele was reported to be associated with increased IL4 gene promoter activity compared with the C allele, our data indicate that genetic differences in transcriptional activity of the IL4 gene influence AD predisposition, particularly in Japanese, because of a high frequency of the T allele.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.