Evidence map›Paper›PMID 9642202›Full record

ArticleJournal of bacteriology1998

Does disparate occurrence of autoregulatory programmed frameshifting in decoding the release factor 2 gene reflect an ancient origin with loss in independent lineages?

B C Persson, J F Atkins

Abstract read
In one paragraph

Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

B C PerssonHoward Hughes Medical Institute, University of Utah, Salt Lake City 84112-5330, USA.
J F Atkins

Funding

RECODING--DYNAMIC REPROGRAMMING OF GENETIC READOUTR01GM048152 · NIGMS · UNIVERSITY OF UTAH · PI ATKINS, JOHN F. · 1992 to 2004
$2.1M
NIGMS NIH HHS R01 GM048152NIGMS NIH HHS R01-GM48152-05
6 · The paper itself

Abstract

In Escherichia coli an autoregulatory mechanism of programmed ribosomal frameshifting governs the level of polypeptide chain release factor 2. From an analysis of 20 sequences of genes encoding release factor 2, we infer that this frameshift mechanism was present in a common ancestor of a large group of bacteria and has subsequently been lost in three independent lineages.

Indexed as

Evolution, MolecularFrameshift MutationPhylogenyAmino Acid SequenceBacteriaBase SequenceConserved SequenceHomeostasisMolecular Sequence DataPeptide Termination FactorsRibosomesSequence AlignmentSequence Homology, Amino AcidSequence Homology, Nucleic Acidpeptide chain termination release factor 2Peptide Termination Factors

Identifiers

PMID9642202
PMCPMC107304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.