ArticleJournal of bacteriology1998
Regulation of switching frequency and bias of the bacterial flagellar motor by CheY and fumarate.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias ineLife · 2021Article
- Article
- A Mechanism of Modulating the Direction of Flagellar Rotation in Bacteria by Fumarate and Fumarate Reductase.Journal of molecular biology · 2019Article
- Impact of fluorescent protein fusions on the bacterial flagellar motor.Scientific reports · 2017Article
- Diverse populations of lake water bacteria exhibit chemotaxis towards inorganic nutrients.The ISME journal · 2013Article
- Energy complexes are apparently associated with the switch-motor complex of bacterial flagella.Journal of molecular biology · 2012Article
- Evolution of response dynamics underlying bacterial chemotaxis.BMC evolutionary biology · 2011Article
- Function of a chemotaxis-like signal transduction pathway in modulating motility, cell clumping, and cell length in the alphaproteobacterium Azospirillum brasilense.Journal of bacteriology · 2008Article
- Cell surface structures of archaea.Journal of bacteriology · 2008Review
- Evolution of taxis responses in virtual bacteria: non-adaptive dynamics.PLoS computational biology · 2008Article
- The bacterial flagellar switch complex is getting more complex.The EMBO journal · 2008Article
- Inverse regulation of biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.Journal of bacteriology · 2007Article
- Functional analysis of nine putative chemoreceptor proteins in Sinorhizobium meliloti.Journal of bacteriology · 2007Article
- Differential activation of Escherichia coli chemoreceptors by blue-light stimuli.Journal of bacteriology · 2006Article
- A quantitative model of the switch cycle of an archaeal flagellar motor and its sensory control.Biophysical journal · 2005Article
- Diversity in chemotaxis mechanisms among the bacteria and archaea.Microbiology and molecular biology reviews : MMBR · 2004Review
- Signal processing and flagellar motor switching during phototaxis of Halobacterium salinarum.Genome research · 2003Article
- Car: a cytoplasmic sensor responsible for arginine chemotaxis in the archaeon Halobacterium salinarum.The EMBO journal · 1999Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of CheY and fumarate on switching frequency and rotational bias of the bacterial flagellar motor was analyzed by computer-aided tracking of tethered Escherichia coli. Plots of cells overexpressing CheY in a gutted background showed a bell-shaped correlation curve of Switching frequency and bias centering at about 50% clockwise rotation. Gutted cells (i.e., with cheA to cheZ deleted) with a low CheY level but a high cytoplasmic fumarate concentration displayed the same correlation of switching frequency and bias as cells overexpressing CheY at the wild-type fumarate level. Hence, a high fumarate level can phenotypically mimic CheY overexpression by simultaneously changing the switching frequency and the bias. A linear correlation of cytoplasmic fumarate concentration and clockwise rotation bias was found and predicts exclusively counter-clockwise rotation without switching when fumarate is absent. This suggests that (i) fumarate is essential for clockwise rotation in vivo and (ii) any metabolically induced fluctuation of its cytoplasmic concentration will result in a transient change in bias and switching probability. A high fumarate level resulted in a dose-response curve linking bias and cytoplasmic CheY concentration that was offset but with a slope similar to that for a low fumarate level. It is concluded that fumarate and CheY act additively presumably at different reaction steps in the conformational transition of the switch complex from counterclockwise to clockwise motor rotation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.