ArticleEnvironmental health perspectives1998
A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.
Article in Environmental health perspectives, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 117 citations in OpenAlex.
- Mutations ofJournal of veterinary research · 2021Article
- Anticancer and immunomodulatory effect of rhaponticin on Benzo(a)Pyrene-induced lung carcinogenesis and induction of apoptosis in A549 cells.Saudi journal of biological sciences · 2021Article
- 2020 Innovation-Based Optimism for Lung Cancer Outcomes.The oncologist · 2021Review
- The oncogenic potential of a mutant TP53 gene explored in two spontaneous lung cancer mice models.BMC cancer · 2020Article
- DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans.Mass spectrometry reviews · 2020Review
- Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer.International journal of molecular sciences · 2017Review
- Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors.JCO precision oncology · 2017Article
- The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival.Scientific reports · 2016Article
- Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal.Toxicologic pathology · 2015Article
- Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.Molecular and cellular biology · 2011Article
- Large cell lung carcinoma with unusual imaging feature, immunophenotype and genetic finding.Pathology oncology research : POR · 2011Article
- TP53 mutations in nonsmall cell lung cancer.Journal of biomedicine & biotechnology · 2011Review
- Formation and repair of tobacco carcinogen-derived bulky DNA adducts.Journal of nucleic acids · 2010Article
- Lung cancer in never smokers: molecular profiles and therapeutic implications.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Review
- Expression of a mutant p53 results in an age-related demographic shift in spontaneous lung tumor formation in transgenic mice.PloS one · 2009Article
- Molecular epidemiology to better predict lung cancer risk.Clinical lung cancer · 2008Review
- Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns.Carcinogenesis · 2007Review
- Clinical implication of p53 mutation in lung cancer.Molecular biotechnology · 2003Review
- Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice.Oncogene · 2002Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the p53 gene are common in lung cancer. Using data from the the International Agency for Research on Cancer p53 mutation database (R1), we have analyzed the distribution and nature of p53 mutations in 876 lung tumors described in the literature. These analyses confirm that G to T transitions are the predominant type of p53 mutation in lung cancer from smokers. The most frequently mutated codons include 157, 158, 179, 248, 249, and 273, and several of them (157, 248, and 273) have been shown to correspond to sites of in vitro DNA adduct formation by metabolites of polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene. Furthermore, most of the base changes at codons 248, 249, and 273 in lung cancer differ from those commonly observed at these codons in other cancers reported in the database. Thus, lung cancer from smokers shows a distinct, unique p53 mutation spectrum that is not observed in lung cancer from nonsmokers. These results further strengthen the association between active smoking, exposure to PAHs, and lung cancer. They also indicate that a different pattern of mutations occurs in nonsmokers, and this observation may help to identify other agents causally involved in lung cancer in nonsmokers.
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