ArticleThe Journal of clinical investigation1998
Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation.
Article in The Journal of clinical investigation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 69 citations in OpenAlex.
- Anti-TNFα alters the natural history of experimental Crohn's disease in rats when begun early, but not late, in disease.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- Cellular and molecular mechanisms of intestinal fibrosis.World journal of gastroenterology · 2012Article
- Intestinal myofibroblasts: targets for stem cell therapy.American journal of physiology. Gastrointestinal and liver physiology · 2011Review
- Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.Endocrinology · 2011Article
- Monocyte chemoattractant protein-1 is generated via TGF-beta by myofibroblasts in gastric intestinal metaplasia and carcinoma without H. pylori infection.Cancer science · 2010Article
- Immunohistochemical study of NG2 chondroitin sulfate proteoglycan expression in the small and large intestines.Histochemistry and cell biology · 2006Article
- Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response.Journal of gastroenterology · 2005Review
- Intestinal subepithelial myofibroblasts in inflammatory bowel diseases.Journal of gastroenterology · 2002Article
- Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor.British journal of pharmacology · 2002Article
- Effect of interlukin-1beta on proliferation of gastric epithelial cells in culture.BMC gastroenterology · 2002Article
- Article
- Tumor necrosis factor-alpha induces stress fiber formation through ceramide production: role of sphingosine kinase.Molecular biology of the cell · 2001Article
- Growth modulation of fibroblasts by chitosan-polyvinyl pyrrolidone hydrogel: implications for wound management?Journal of biosciences · 2000Article
- Myofibroblasts: paracrine cells important in health and disease.Transactions of the American Clinical and Climatological Association · 2000Review
- The role of myofibroblasts in the progression of oral submucous fibrosis: A systematic review.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
An increase in myofibroblast number may be necessary for wound healing but may also lead to postinflammatory scarring. We have, therefore, studied the role of mediators important in inflammatory bowel disease in regulating proliferation of human colonic myofibroblasts. Using primary cultures of these cells, we have shown increases in [3H]thymidine incorporation in response to platelet-derived growth factor (EC50 = 14 ng/ml), basic fibroblast growth factor (EC50 = 2.2 ng/ml), and epidermal growth factor (EC50 = 1.1 ng/ml). Coulter counting of cell suspensions demonstrated increases in cell number with these growth factors along with insulin-like growth factor-I and -II. In addition the proinflammatory cytokines IL-1beta and TNF-alpha produced increases in [3H]thymidine incorporation. IL-1beta and platelet-derived growth factor together produced an increase in [3H]thymidine greater than either agonist alone; this effect was not, however, seen when we examined changes in cell numbers. Finally, we demonstrate a mechanism whereby these responses may be downregulated: vasoactive intestinal peptide (1 microM) elevates cyclic AwMP in these cells 4. 2-fold over control and produces a dose-related inhibition of platelet-derived growth factor-driven proliferation with a maximum inhibition of 33% at 1 microM.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.