ArticleGenes & development1998
Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.
Article in Genes & development, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 93 citations in OpenAlex.
- Transcriptional Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Early patterning followed by tissue growth establishes distal identity inFrontiers in cell and developmental biology · 2022Article
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Article
- Seven-Up Is a Novel Regulator of Insulin Signaling.Genetics · 2018Article
- Juvenile hormone biosynthesis in adult Blattella germanica requires nuclear receptors Seven-up and FTZ-F1.Scientific reports · 2017Article
- CONSERVED AND EXAPTED FUNCTIONS OF NUCLEAR RECEPTORS IN ANIMAL DEVELOPMENT.Nuclear receptor research · 2017Article
- Genes implicated in stem cell identity and temporal programme are directly targeted by Notch in neuroblast tumours.Development (Cambridge, England) · 2016Article
- Gene Regulatory Mechanisms Underlying the Spatial and Temporal Regulation of Target-Dependent Gene Expression in Drosophila Neurons.PLoS genetics · 2015Article
- Epidermal growth factor signalling controls myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis.PLoS biology · 2014Article
- Tip cells: master regulators of tubulogenesis?Seminars in cell & developmental biology · 2014Review
- Regulatory potential of COUP-TFs in development: stem/progenitor cells.Seminars in cell & developmental biology · 2013Review
- Tip cells act as dynamic cellular anchors in the morphogenesis of looped renal tubules in Drosophila.Developmental cell · 2013Article
- Expression and retinoic acid regulation of the zebrafish nr2f orphan nuclear receptor genes.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Progressive polycomb assembly on H3K27me3 compartments generates polycomb bodies with developmentally regulated motion.PLoS genetics · 2012Article
- Identification of a role for the nuclear receptor EAR-2 in the maintenance of clonogenic status within the leukemia cell hierarchy.Leukemia · 2011Article
- Support for the reproductive ground plan hypothesis of social evolution and major QTL for ovary traits of Africanized worker honey bees (Apis mellifera L.).BMC evolutionary biology · 2011Article
- Involvement of COUP-TFs in Cancer Progression.Cancers · 2011Article
- The function of nuclear receptors in regulation of female reproduction and embryogenesis in the red flour beetle, Tribolium castaneum.Journal of insect physiology · 2010Article
- Bringing together components of the fly renal system.Current opinion in genetics & development · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenesis of the insect kidney, the Malpighian tubules, is controlled in Drosophila by a single large cell, the tip cell. It has been postulated that this cell sends out a mitogenic signal that induces the division of neighboring cells. The signal and the molecules that receive it have remained elusive. We show that the COUP-TF-related nuclear orphan receptor Seven-up is a key component that becomes induced in response to mitogenic EGF receptor signaling activity emanating from the tip cell. Seven-up in turn is capable of regulating the transcription of cell cycle regulators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.