ArticleMutation research1998
Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae.
Article in Mutation research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.Molecular and cellular biology · 2004Article
- Article
- Strand bias in targeted gene repair is influenced by transcriptional activity.Molecular and cellular biology · 2002Article
- Inactivation of DNA mismatch repair by increased expression of yeast MLH1.Molecular and cellular biology · 2001Article
- Mouse mismatch repair gene Msh2 is not essential for transcription-coupled repair of UV-induced cyclobutane pyrimidine dimers.Oncogene · 2001Article
- Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA.The Plant cell · 2000Article
- Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Physical interaction between components of DNA mismatch repair and nucleotide excision repair.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Replication errors: cha(lle)nging the genome.The EMBO journal · 1998Review
Corrections and comments
- Correction · 2003-08-09Concerns/Issues about Authorship/Affiliation · Investigation by ORI · Lack of Approval from Author · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Journal previously known as 'Mutation research: Genetic Toxicology and Environmental Mutagenesis - DNA Repair'; Steven A Leadon has ORI finding of misconduct; See also: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259672/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019656/
- Retraction · 2003-03-01Error in Results and/or Conclusions · Falsification/Fabrication of Image · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · Unreliable Results and/or Conclusions · · Journal previously known as 'Mutation research: Genetic Toxicology and Environmental Mutagenesis - DNA Repair'; Steven Anthony Leadon has ORI finding of misconduct; See also: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259672/ and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019656/
- Commented on by
- Commented on by
- RetractedRetraction.2003
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Defects in DNA mismatch repair have been shown to lead to increased genomic instability and mutability. We recently found that human cells defective in the DNA mismatch repair gene, hMSH2, were deficient in the transcription-coupled repair (TCR) of both oxidative DNA damage, including thymine glycols, and UV-induced DNA damage. However, in a hMLH1 mutant, only a reduction in the TCR of UV damage was observed. In this study, we examined whether TCR of thymine glycols in Saccharomyces cerecisiae also requires the genes involved in DNA mismatch repair. We found that yeast cells containing mutations in MSH2 were deficient in the removal of thymine glycols from the transcribed strand of the RPB2 gene, while cells with mutations in either MLH1 or PMS1 alone showed near normal levels of TCR of thymine glycols. Interestingly, double mutants in the MLH1 and PMS1 genes were deficient in TCR of thymine glycols. Taken together, these results suggest that these two MutL homologues can act independently of each other, but that they have overlapping roles in TCR. Overall levels of thymine glycol removal were not reduced in the mismatch repair mutants. In contrast to the results with thymine glycols, no defects in TCR of pyrimidine dimers were found in cells with mutations in MSH2, MLH1, PMS1, and MLH1/PMS1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.