ArticleProceedings of the National Academy of Sciences of the United States of America1998
KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- The Ku complex: recent advances and emerging roles outside of non-homologous end-joining.Cellular and molecular life sciences : CMLS · 2021Review
- Resolving DNA Damage: Epigenetic Regulation of DNA Repair.Molecules (Basel, Switzerland) · 2020Review
- Sepantronium is a DNA damaging agent that synergizes with PLK1 inhibitor volasertib.American journal of cancer research · 2014Article
- Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation.Nucleic acids research · 2013Review
- A global genomic view on LNX siRNA-mediated cell cycle arrest.Molecular biology reports · 2011Article
- An investigation of hormesis of trichloroethylene in L-02 liver cells by differential proteomic analysis.Molecular biology reports · 2009Article
- The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation.Journal of cellular and molecular medicine · 2009Review
- Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage.Molecular and cellular biology · 2004Article
- Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element.Nucleic acids research · 2002Article
- Novel mutations and defective protein kinase C activation of T-lymphocytes in ataxia telangiectasia.Clinical and experimental immunology · 2001Article
- Article
- Molecular interaction map of the mammalian cell cycle control and DNA repair systems.Molecular biology of the cell · 1999Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus. These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.