ArticleProceedings of the National Academy of Sciences of the United States of America1998
A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 98 citations in OpenAlex.
- Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells.iScience · 2023Article
- Capturing the Asc1p/Molecular & cellular proteomics : MCP · 2017Article
- mRNA quality control is bypassed for immediate export of stress-responsive transcripts.Nature · 2016Article
- Review
- Article
- The intrinsic GTPase activity of the Gtr1 protein from Saccharomyces cerevisiae.BMC biochemistry · 2012Article
- Human T lymphotropic virus type 1 regulatory and accessory gene transcript expression and export are not rex dependent.AIDS research and human retroviruses · 2012Article
- Ran-dependent nuclear export mediators: a structural perspective.The EMBO journal · 2011Review
- Article
- An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.The EMBO journal · 2010Article
- Nuclear export receptor Xpo1/Crm1 is physically and functionally linked to the spindle pole body in budding yeast.Molecular and cellular biology · 2008Article
- Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits.Molecular and cellular biology · 2008Article
- Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport.The Journal of cell biology · 2007Article
- Mechanism underlying the iron-dependent nuclear export of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae.Molecular biology of the cell · 2007Article
- Crm1-mediated nuclear export of the Schizosaccharomyces pombe transcription factor Cuf1 during a shift from low to high copper concentrations.Eukaryotic cell · 2007Article
- Analysis of a predicted nuclear localization signal: implications for the intracellular localization and function of the Saccharomyces cerevisiae RNA-binding protein Scp160.Nucleic acids research · 2007Article
- Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae.Genetics · 2006Article
- RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1.The Journal of cell biology · 2005Article
- The human T-cell leukemia virus Rex protein.Frontiers in bioscience : a journal and virtual library · 2005Review
- Sam68 is absolutely required for Rev function and HIV-1 production.Nucleic acids research · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yeast cells mutated in YRB2, which encodes a nuclear protein with similarity to other Ran-binding proteins, fail to export nuclear export signal (NES)-containing proteins including HIV Rev out of the nucleus. Unlike Xpo1p/Crm1p/exportin, an NES receptor, Yrb2p does not shuttle between the nucleus and the cytoplasm but instead remains inside the nucleus. However, by both biochemical and genetic criteria, Yrb2p interacts with Xpo1p and not with other members of the importin/karyopherin beta superfamily. Moreover, the Yrb2p region containing nucleoporin-like FG repeats is important for NES-mediated protein export. Taken together, these data suggest that Yrb2p acts inside the nucleus to mediate the action of Xpo1p in at least one of several nuclear export pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.