ArticleBiophysical journal1998
Kinetics of synaptic depression and vesicle recycling after tetanic stimulation of frog motor nerve terminals.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 82 citations in OpenAlex.
- Article
- 25-Hydroxycholesterol modulates synaptic vesicle endocytosis at the mouse neuromuscular junction.Pflugers Archiv : European journal of physiology · 2025Article
- Mechanism of Purinergic Regulation of Neurotransmission in Mouse Neuromuscular Junction: The Role of Redox Signaling and Lipid Rafts.Neurochemical research · 2024Article
- Acute adaptation of central and peripheral motor unit features to exercise-induced fatigue differs with concentric and eccentric loading.Experimental physiology · 2023Article
- A high-intensity, intermittent exercise protocol and dynamic postural control in men and women.Journal of athletic training · 2015Article
- A three-pool model dissecting readily releasable pool replenishment at the calyx of held.Scientific reports · 2015Article
- Presynaptic clathrin levels are a limiting factor for synaptic transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Synaptic activity slows vesicular replenishment at excitatory synapses of rat hippocampus.Cognitive neurodynamics · 2013Article
- Article
- Neuromodulatory changes in short-term synaptic dynamics may be mediated by two distinct mechanisms of presynaptic calcium entry.Journal of computational neuroscience · 2012Article
- Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14.American journal of physiology. Cell physiology · 2012Article
- Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation.The Journal of physiology · 2012Article
- A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The number of components of enhancement contributing to short-term synaptic plasticity at the neuromuscular synapse during patterned nerve Stimulation progressively decreases as basal release probability is increased from low to normal levels by changing extracellular Ca2+.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- A kinetic model unifying presynaptic short-term facilitation and depression.Journal of computational neuroscience · 2009Article
- Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons.The Journal of biological chemistry · 2009Article
- The vesicle cycle in motor nerve endings of the mouse diaphragm.Neuroscience and behavioral physiology · 2009Article
- A heterogeneous "resting" pool of synaptic vesicles that is dynamically interchanged across boutons in mammalian CNS synapses.Brain cell biology · 2008Article
- Interactions between multiple sources of short-term plasticity during evoked and spontaneous activity at the rat calyx of Held.The Journal of physiology · 2008Article
- Truncations of amphiphysin I by calpain inhibit vesicle endocytosis during neural hyperexcitation.The EMBO journal · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We measured the time courses of two key components of the synaptic vesicle cycle during recovery from synaptic depression under different conditions, and used this and other information to create a kinetic model of the vesicle cycle. End plate potential (EPP) amplitudes were used to follow recovery from synaptic depression after different amounts of tetanic stimulation. This provided an estimate of the time course of vesicle mobilization from the reserve pool to the docked (readily releasable) pool. In addition, FM1-43 was used to measure the rate of membrane retrieval after tetanic stimulation, and the amount of membrane transferred to the surface membrane. This provided a measure of the rate of refilling of the reserve pool with recycled vesicles. The time courses of both synaptic depression and endocytosis were slowed by prolonged tetanic stimulation. This behavior could be fitted by a simple model, assuming a first-order kinetics for both vesicle endocytosis and mobilization. The results show that a nearly 20-fold decrease in the rate constant of endocytosis greatly delays refilling of the depleted reserve pool. However, to fully account for the slower recovery of depression, a decrease in the rate constant of vesicle mobilization from the reserve pool of about sixfold is also required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.