ArticleThe Plant cell1998
Characterization of microtubule binding domains in the Arabidopsis kinesin-like calmodulin binding protein.
Article in The Plant cell, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 95 citations in OpenAlex.
- Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesis.The Journal of cell biology · 2026Article
- A New Allele of theFrontiers in plant science · 2019Article
- The IQD Family of Calmodulin-Binding Proteins Links Calcium Signaling to Microtubules, Membrane Subdomains, and the Nucleus.Plant physiology · 2017Article
- Myosin MyTH4-FERM structures highlight important principles of convergent evolution.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Cytoskeleton and Its Regulation by Calcium and Protons.Plant physiology · 2016Review
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- The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development.Acta crystallographica. Section D, Biological crystallography · 2014Article
- Article
- Myosin-X: a MyTH-FERM myosin at the tips of filopodia.Journal of cell science · 2011Review
- Characterization of a myosin VII MyTH/FERM domain.Journal of molecular biology · 2011Article
- An unconventional myosin required for cell polarization and chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Myosin X regulates sealing zone patterning in osteoclasts through linkage of podosomes and microtubules.The Journal of biological chemistry · 2010Article
- Structure of the complex of a mitotic kinesin with its calcium binding regulator.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The kinesin ATK5 functions in early spindle assembly in Arabidopsis.The Plant cell · 2007Article
- Origin and evolution of Kinesin-like calmodulin-binding protein.Plant physiology · 2005Article
- A minus-end-directed kinesin with plus-end tracking protein activity is involved in spindle morphogenesis.Molecular biology of the cell · 2005Article
- A plant-specific subclass of C-terminal kinesins contains a conserved a-type cyclin-dependent kinase site implicated in folding and dimerization.Plant physiology · 2004Article
- Developmental and cell-specific expression of ZWICHEL is regulated by the intron and exon sequences of its gene.Plant molecular biology · 2004Article
- KIC, a novel Ca2+ binding protein with one EF-hand motif, interacts with a microtubule motor protein and regulates trichome morphogenesis.The Plant cell · 2004Article
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinesin-like calmodulin binding protein (KCBP) is a new member of the kinesin superfamily that appears to be present only in plants. The KCBP is unique in its ability to interact with calmodulin in a Ca2+-dependent manner. To study the interaction of the KCBP with microtubules, we expressed different regions of the Arabidopsis KCBP and used the purified proteins in cosedimentation assays with microtubules. The motor domain with or without the calmodulin binding domain bound to microtubules. The binding of the motor domain containing the calmodulin binding region to microtubules was inhibited by Ca2+-calmodulin. This Ca2+-calmodulin regulation of motor domain interactions with microtubules was abolished in the presence of antibodies specific to the calmodulin binding region. In addition, the binding of the motor domain lacking the calmodulin binding region to microtubules was not inhibited in the presence of Ca2+-calmodulin, suggesting an essential role for the calmodulin binding region in Ca2+-calmodulin modulation. Results of the cosedimentation assays with the N-terminal tail suggest the presence of a second microtubule binding site on the KCBP. However, the interaction of the N-terminal tail region of the KCBP with microtubules was insensitive to ATP. These data on the interaction of the KCBP with microtubules provide new insights into the functioning of the KCBP in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.