ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Axon withdrawal during synapse elimination at the neuromuscular junction is accompanied by disassembly of the postsynaptic specialization and withdrawal of Schwann cell processes.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 75 citations in OpenAlex.
- Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular Junction.Molecular neurobiology · 2023Article
- Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction.Aging and disease · 2021Review
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function.Physiological reviews · 2019 · on this mapReview
- Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling.Nature communications · 2018Article
- Limitations and Challenges in Modeling Diseases Involving Spinal Motor Neuron DegenerationFrontiers in cellular neuroscience · 2018Article
- Presynaptic Membrane Receptors Modulate ACh Release, Axonal Competition and Synapse Elimination during Neuromuscular Junction Development.Frontiers in molecular neuroscience · 2017Review
- Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells.Cold Spring Harbor perspectives in biology · 2015Review
- Photoreceptor ablation initiates the immediate loss of glutamate receptors in postsynaptic bipolar cells in retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- LRP4 is critical for neuromuscular junction maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis.The Journal of clinical investigation · 2013Article
- Terminal Schwann cells participate in the competition underlying neuromuscular synapse elimination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Axotomy or compression is required for axonal sprouting following end-to-side neurorrhaphy.Experimental neurology · 2008Article
- Rapid synapse elimination after postsynaptic protein synthesis inhibition in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Primary afferent synapses on developing and adult Renshaw cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Functional analysis of neurotransmission at beta2-laminin deficient terminals.The Journal of physiology · 2003Article
- Stability and plasticity of developing synapses in hippocampal neuronal cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The Glial Scar: To Penetrate or Not for Motor Pathway Restoration?Cell transplantationReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve terminal withdrawal is accompanied by a loss of acetylcholine receptors (AChRs) at corresponding postsynaptic sites during the process of synapse elimination at developing () and reinnervated adult () neuromuscular junctions. Aside from AChR and nerve terminal loss, however, the molecular and cellular alterations that occur at sites of elimination are unknown. To gain a better understanding of the cascade of events that leads to the disassembly of synaptic sites during the synapse elimination process, we surveyed the distribution of molecular elements of the postsynaptic specialization, the basal lamina, and supporting Schwann cells during the process of synapse elimination that occurs after reinnervation. In addition, quantitative techniques were used to determine the temporal order of disappearance of molecules that were lost relative to the loss of postsynaptic AChRs. We found that the dismantling of the postsynaptic specialization was inhomogeneous, with evidence of rapid dissolution of some aspects of the postsynaptic apparatus and slower loss of others. We also observed a loss of Schwann cell processes from sites of synapse elimination, with a time course similar to that seen for nerve terminal retraction. In contrast, all of the extracellular markers that we examined were lost slowly from sites of synapse loss. We therefore conclude that the synapse elimination process is synapse-wide, removing not only nerve terminals but also Schwann cells and many aspects of the postsynaptic apparatus. The disassembly occurs in a stereotyped sequence with some synaptic elements appearing much more stable than others.
Indexed as
Identifiers
9634561PMC6792572W1524071937What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.