ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Ca2+ channel beta3 subunit enhances voltage-dependent relief of G-protein inhibition induced by muscarinic receptor activation and Gbetagamma.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Stargazin modulates neuronal voltage-dependent Ca(2+) channel Ca(v)2.2 by a Gbetagamma-dependent mechanism.The Journal of biological chemistry · 2010Article
- Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Introduction into Ca(v)2.1 of the homologous mutation of Ca(v)1.2 causing the Timothy syndrome questions the role of V421 in the phenotypic definition of P-type Ca(2+) channel.Pflugers Archiv : European journal of physiology · 2008Article
- The lipid connection-regulation of voltage-gated Ca(2+) channels by phosphoinositides.Pflugers Archiv : European journal of physiology · 2007Review
- Beta subunits of voltage-gated calcium channels.Journal of bioenergetics and biomembranes · 2003Review
- Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation.The EMBO journal · 2003Article
- Ca2+-independent feedback inhibition of acetylcholine release in frog neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Evidence for two concentration-dependent processes for beta-subunit effects on alpha1B calcium channels.Biophysical journal · 2001Article
- G protein modulation of recombinant P/Q-type calcium channels by regulators of G protein signalling proteins.The Journal of physiology · 2000Article
- Interaction between G proteins and accessory subunits in the regulation of 1B calcium channels in Xenopus oocytes.The Journal of physiology · 2000Article
- Calcium channel beta subunit promotes voltage-dependent modulation of alpha 1 B by G beta gamma.Biophysical journal · 2000Article
- Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Sequestration of G-protein beta gamma subunits by different G-protein alpha subunits blocks voltage-dependent modulation of Ca2+ channels in rat sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Ca2+ channel beta subunit has been shown to reduce the magnitude of G-protein inhibition of Ca2+ channels. However, neither the specificity of this action to different forms of G-protein inhibition nor the mechanism underlying this reduction in response is known. We have reported previously that coexpression of the Ca2+ channel beta3 subunit causes M2 muscarinic receptor-mediated inhibition of alpha1B Ca2+ currents to become more voltage-dependent. We report here that the beta3 subunit increases the rate of relief of inhibition produced by a depolarizing prepulse and also shifts the voltage dependency of this relief to more hyperpolarized voltages; these effects are likely to be responsible for the reduction of inhibitory response of alpha1B channels to G-protein-mediated inhibition seen after coexpression of the Ca2+ channel beta3 subunit. Additionally, the beta3 subunit alters the rate and voltage dependency of relief of the inhibition produced by coexpressed Gbeta1gamma1, in a manner similar to the changes it produces in relief of M2 receptor-induced inhibition. We conclude that the Ca2+ channel beta3 subunit reduces the magnitude of G-protein inhibition of alpha1B Ca2+ channels by enhancing the rate of dissociation of the G-protein betagamma subunit from the Ca2+ channel alpha1B subunit.
Indexed as
Identifiers
9634554PMC6792574W1944892775What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.